Table 3.

Screening and prostate cancer mortality outcomes in the projected population (N = 10,000) when PCA3 varies by grade, for select strategies from Table 2

StrategyLG median PCA3M-HG median PCA3LG sensitivity of PCA3M-HG sensitivity of PCA3LG cases detectedM-HG cases detectedOverdiagnosesProstate cancer deathsLives saved
PSA(4)+PCA3(20)50500.7580.758531389291223130
30850.6300.850443437272223130
201030.5000.874353449241228125
PSA(4)+PCA3(35)50500.6160.616431316237247105
30850.4450.752312386211246107
201030.2970.790211406178250103

NOTE: Grade-specific sensitivities refer to the PCA3 test properties alone. Grade is either LG or M-HG.