Table 3.

SSB, other high-sugar food/drink, and sugar intake and type I endometrial cancer

Intake levela (quintile)HR (95% CI)
Food groupsRangeMedianCasesModel 1bModel 2cModel 3d
SSB (servings/wk)00761.00 (ref.)1.00 (ref.)1.00 (ref.)
>0–0.010.0071011.34 (0.99–1.82)1.42 (1.05–1.93)1.34 (0.96–1.86)
0.02–0.60.41051.42 (1.04–1.86)1.48 (1.09–2.02)1.36 (0.98–1.89)
0.7–1.61.01011.37 (1.00–1.86)1.49 (1.09–2.03)1.40 (1.01–1.94)
1.7–60.53.31231.72 (1.28–2.32)1.78 (1.32–2.40)1.74 (1.27–2.38)
Ptrend0.0010.00050.001
Fruit juice (servings/wk)0–0.60.006861.00 (ref.)1.00 (ref.)1.00 (ref.)
0.7–2.41.4931.04 (0.77–1.40)1.05 (0.78–1.41)0.96 (0.70–1.31)
2.5–5.03.71111.24 (0.93–1.65)1.25 (0.94–1.67)1.19 (0.88–1.61)
5.1–8.36.61111.20 (0.90–1.60)1.27 (0.95–1.70)1.23 (0.91–1.67)
8.4–63.010.81051.10 (0.82–1.47)1.16 (0.87–1.56)1.18 (0.87–1.61)
Ptrend0.340.140.09
SSB + fruit juice (servings/wk)0–1.30.5761.00 (ref.)1.01.00 (ref.)
1.4–3.62.41041.35 (1.00–1.83)1.40 (1.03–1.90)1.36 (0.99–1.88)
3.7–6.25.01061.38 (1.02–1.87)1.46 (1.08–1.98)1.45 (1.05–2.00)
6.3–9.87.91081.37 (1.01–1.85)1.47 (1.09–1.99)1.52 (1.10–2.09)
9.9–72.313.01121.38 (1.03–1.87)1.48 (1.09–2.00)1.54 (1.12–2.12)
Ptrend0.060.020.008
Sugar-free beverages (servings/wk)001521.00 (ref.)1.00 (ref.)1.00 (ref.)
>0–0.00020.0001360.72 (0.49–1.04)0.69 (0.48–1.00)0.73 (0.50–1.06)
0.0003–0.40.0008930.93 (0.71–1.21)0.85 (0.65–1.11)0.86 (0.65–1.13)
0.5–2.81.01251.17 (0.92–1.50)1.03 (0.80–1.32)0.99 (0.76–1.28)
2.8–64.15.61000.96 (0.74–1.26)0.77 (0.59–1.01)0.80 (0.60–1.06)
Ptrend0.490.310.35
Sweets/baked goods (servings/wk)0–2.71.5941.00 (ref.)1.00 (ref.)1.00 (ref.)
2.8–5.04.0941.01 (0.75–1.36)1.00 (0.75–1.35)0.93 (0.68–1.29)
5.1–7.66.31171.18 (0.88–1.57)1.20 (0.90–1.60)1.16 (0.86–1.58)
7.7–11.89.41001.06 (0.79–1.43)1.08 (0.81–1.45)1.07 (0.79–1.47)
11.9–91.815.91011.03 (0.77–1.39)1.11 (0.83–1.49)1.08 (0.79–1.48)
Ptrend0.770.410.40
Starch (g/d)2.8–47.240.01051.00 (ref.)1.00 (ref.)1.00 (ref.)
47.3–56.652.4950.80 (0.60–1.07)0.83 (0.63–1.11)0.79 (0.59–1.08)
56.7–64.960.81040.90 (0.69–1.19)0.95 (0.72–1.26)0.92 (0.69–1.23)
65.0–75.069.61060.96 (0.73–1.26)1.00 (0.76–1.32)0.94 (0.70–1.26)
75.1–233.283.6960.84 (0.63–1.11)0.92 (0.69–1.22)0.94 (0.70–1.27)
Ptrend0.570.970.89
Sucrose (g/d)1.3–28.423.5951.00 (ref.)1.00 (ref.)1.00 (ref.)
28.5–35.332.2880.83 (0.62–1.13)0.83 (0.62–1.12)0.93 (0.67–1.29)
35.4–41.238.3980.92 (0.68–1.23)0.98 (0.73–1.31)1.04 (0.75–1.43)
41.3–49.244.81081.00 (0.75–1.33)1.08 (0.81–1.44)1.15 (0.84–1.58)
49.3–165.355.81171.05 (0.79–1.40)1.16 (0.87–1.54)1.23 (0.90–1.69)
Ptrend0.370.090.06
Glucose (g/d)1.0–12.910.3711.00 (ref.)1.00 (ref.)1.00 (ref.)
13.0–16.815.01101.42 (1.05–1.93)1.47 (1.09–2.00)1.47 (1.06–2.04)
16.9–20.518.71051.33 (0.98–1.81)1.38 (1.02–1.89)1.40 (1.01–1.95)
20.6–25.322.61101.40 (1.03–1.90)1.47 (1.08–2.00)1.47 (1.06–2.04)
25.4–118.729.51101.31 (0.96–1.78)1.41 (1.03–1.92)1.50 (1.08–2.08)
Ptrendc0.200.080.04
Fructose (g/d)0.9–14.811.6841.00 (ref.)1.00 (ref.)1.00 (ref.)
14.9–19.517.31011.14 (0.84–1.53)1.17 (0.87–1.57)1.24 (0.02–1.70)
19.6–23.721.71021.14 (0.84–1.53)1.18 (0.87–1.59)1.23 (0.90–1.70)
23.8–29.328.21051.13 (0.84–1.53)1.18 (0.87–1.59)1.28 (0.93–1.76)
29.4–129.534.91141.16 (0.86–1.56)1.23 (0.92–1.66)1.32 (0.96–1.82)
Ptrend0.420.220.11
  • aAdjusted for total energy intake using nutrient residual methods.

  • bAdjusted for age, smoking (never, past, and current), physical activity (low, medium, or high), alcohol use (none, <4 g/day, or ≥4 g/day), estrogen use (never, ever), age at menarche (≤12 or >12 years), age at menopause (<50 or ≥50 years), number of live births, history of diabetes, and coffee intake.

  • cModel 1 plus adjustment for BMI.

  • dAnalysis excluding women who reported history of diabetes at baseline; adjusted for covariates included in Model 2 (except history of diabetes).