Table 4.

SSB, other high-sugar food/drink, and sugar intake and type II endometrial cancer

Intake levela (quintile)HR (95% CI)
Food groupsRangeMedianCasesModel 1bModel 2cModel 3d
SSB (servings/wk)00131.00 (ref.)1.00 (ref.)1.00 (ref.)
>0–0.010.007231.65 (0.83–3.27)1.69 (0.85–3.35)1.88 (0.91–3.91)
0.02–0.60.4130.88 (0.40–1.93)0.89 (0.40–1.95)0.92 (0.40–2.12)
0.7–1.61.0191.26 (0.61–2.59)1.31 (0.64–2.69)1.46 (0.69–3.10)
1.7–60.53.3181.31 (0.63–2.69)1.31 (0.63–2.69)1.47 (0.69–3.12)
Ptrend0.810.800.63
Fruit juice (servings/wk)0–0.60.006191.00 (ref.)1.00 (ref.)1.00 (ref.)
0.7–2.41.4130.68 (0.33–1.39)0.69 (0.34–1.42)0.68 (0.32–1.42)
2.5–5.03.7211.01 (0.53–1.93)1.02 (0.54–1.94)0.76 (0.50–1.90)
5.1–8.36.6140.72 (0.36–1.46)0.75 (0.37–1.51)0.80 (0.39–1.64)
8.4–63.010.8190.93 (0.48–1.79)0.97 (0.50–1.88)1.06 (0.54–2.07)
Ptrend0.890.990.73
SSB + fruit juice (servings/wk)0–1.30.5171.00 (ref.)1.00 (ref.)1.00 (ref.)
1.4–3.62.4171.00 (0.50–1.98)1.01 (0.51–2.00)0.93 (0.46–1.91)
3.7–6.25.0170.92 (0.46–1.84)0.94 (0.47–1.88)0.93 (0.45–1.90)
6.3–9.87.9160.91 (0.45–1.82)0.94 (0.47–1.88)1.00 (0.49–2.03)
9.9–72.313.0191.05 (0.53–2.06)1.09 (0.55–2.15)1.17 (0.59–2.34)
Ptrend0.990.890.62
Sugar-free beverages (servings/wk)00271.00 (ref.)1.00 (ref.)1.00 (ref.)
>0–0.00020.000180.79 (0.34–1.83)0.78 (0.34–1.79)0.81 (0.35–1.86)
0.0003–0.40.0008130.69 (0.35–1.37)0.66 (0.33–1.30)0.63 (0.31–1.28)
0.5–2.81.0211.21 (0.68–2.17)1.09 (0.61–1.95)1.16 (0.64–2.09)
2.8–64.15.6171.05 (0.56–1.96)0.89 (0.48–1.68)0.87 (0.45–1.69)
Ptrend0.650.950.97
Sweets/baked goods (servings/wk)0–2.71.5221.00 (ref.)1.00 (ref.)1.00 (ref.)
2.8–5.04.0100.42 (0.20–0.89)0.42 (0.20–0.89)0.31 (0.14–0.70)
5.1–7.66.3271.05 (0.58–1.90)1.07 (0.59–1.94)0.97 (0.54–1.75)
7.7–11.89.4110.44 (0.21–0.92)0.46 (0.22–0.96)0.38 (0.18–0.81)
11.9–91.815.9160.64 (0.33–1.25)0.68 (0.35–1.33)0.58 (0.29–1.13)
Ptrend0.260.350.19
Starch (g/day)2.8–47.240.0161.00 (ref.)1.00 (ref.)1.00 (ref.)
47.3–56.652.4130.75 (0.35–1.60)0.76 (0.56–1.62)0.75 (0.35–1.61)
56.7–64.960.8211.32 (0.68–2.57)1.35 (0.69–2.62)1.16 (0.58–2.31)
65.0–75.069.6201.26 (0.64–2.48)1.29 (0.66–2.52)1.21 (0.62–2.40)
75.1–233.283.6160.96 (0.47–1.97)1.01 (0.49–2.08)1.02 (0.49–2.09)
Ptrend0.600.510.53
Sucrose (g/day)1.3–28.423.5181.00 (ref.)1.00 (ref.)1.00 (ref.)
28.5–35.332.2221.15 (0.60–2.21)1.17 (0.61–2.24)1.28 (0.65–2.50)
35.4–41.238.3160.85 (0.42–1.71)0.89 (0.44–1.79)0.89 (0.43–1.84)
41.3–49.244.8120.57 (0.26–1.24)0.60 (0.28–1.31)0.64 (0.29–1.41)
49.3–165.355.8180.93 (0.47–1.86)1.00 (0.50–1.99)1.00 (0.49–2.05)
Ptrend0.330.450.41
Glucose (g/day)1.0–12.910.3231.00 (ref.)1.00 (ref.)1.00 (ref.)
13.0–16.815.0160.68 (0.36–1.31)0.69 (0.36–1.32)0.72 (0.37–1.42)
16.9–20.518.7110.41 (0.19–0.87)0.41 (0.20–0.88)0.46 (0.22–0.99)
20.6–25.322.6150.62 (0.32–1.21)0.63 (0.33–1.23)0.66 (0.33–1.32)
25.4–118.729.5210.85 (0.46–1.57)0.86 (0.47–1.63)0.99 (0.53–1.88)
Ptrendc0.560.630.92
Fructose (g/day)0.9–14.811.6221.00 (ref.)1.00 (ref.)1.00 (ref.)
14.9–19.517.3200.88 (0.48–1.63)0.88 (0.48–1.63)0.80 (0.42–1.54)
19.6–23.721.7120.48 (0.23–1.00)0.48 (0.23–1.01)0.51 (0.25–1.08)
23.8–29.328.2140.56 (0.28–1.13)0.56 (0.28–1.14)0.61 (0.30–1.23)
29.4–129.534.9180.80 (0.42–1.53)0.83 (0.43–1.57)0.90 (0.47–1.73)
Ptrend0.240.270.53
  • aAdjusted for total energy intake using nutrient residual methods.

  • bAdjusted for age, smoking (never, past, and current), physical activity (low, medium, or high), alcohol use (none, <4 g/day, or ≥4 g/day), estrogen use (never, ever), age at menarche (≤12 or >12 years), age at menopause (<50 or ≥50 years), number of live births, history of diabetes, and coffee intake.

  • cModel 1 plus adjustment for BMI.

  • dAnalysis excluding women who reported history of diabetes at baseline; adjusted for covariates included in Model 2 (except history of diabetes).