Table 5.

Association between immune markers and AIDS-NHL risk at three sampling time-windows

3–5 years1–3 years0–1 year
10 cases/42 controls14 cases/54 controls19 cases/69 controls
ORa (95% CI)OR (95% CI)OR (95% CI)
sCD234.56 (1.14–18.35)1.24 (0.63–2.5)1.45 (0.82–2.58)
sCD273.44 (0.42–28.27)3.41 (0.65–18.01)16.43 (2.93–92.19)
sCD301.80 (0.32–10.41)2.37 (0.68–8.35)2.90 (0.95–8.94)
CXCL131.25 (0.38–4.18)4.40 (1.25–15.61)2.70 (0.91–8.08)
IL-61.94 (0.85–4.47)0.88 (0.43–1.82)2.11 (1.17–3.83)
CRP1.48 (0.76–2.92)0.54 (0.29–1.04)1.01 (0.66–1.56)
  • aThe ORs represent risk of AIDS-NHL associated with one unit increase in the biomarker on the natural log scale. ORs were adjusted for CD4+ T-cell count, HIV load, and HAART exposure at each visit where the biomarker was measured, cigarette smoking, HCV infection, and education, in addition to the matching factors (time since first HIV-positive study visit, age, CD4+ T-cell count at first HIV-positive study visit, and race/ethnicity).