Table 3.

Serum metabolites examined in the training set study

PCHV
MeanSEMMeanSEMaFold inductionbP
1Pyruvate + Oxalacetic acid0.0414230.003070.0367240.002691.130.1507
2Lactic acid0.838820.072230.734040.077041.140.1830
3Glycolic acid0.0129960.000610.0133920.000570.970.5297
4Glycine (2TMS)0.0023170.000150.0023720.000080.980.3227
5Hydroxybutyrate0.1033070.011610.1067090.020220.970.9474
63-Hydroxybutyrate0.3621710.066010.2124650.039551.700.3142
7Valine (2TMS)0.6992450.041420.867640.034250.810.0009
82-Aminoethanol0.0318010.00170.0350650.001260.910.0283
9n-Caprylic acid0.0022910.000130.0029870.000170.770.0019
10Glycerol0.1416850.009470.1643320.012020.860.1918
11Phosphate0.228820.018060.2455220.012460.930.0630
12Threonine (2TMS)0.0323220.001450.0373780.001870.860.0385
13Proline0.5107970.029390.5789640.040470.880.3447
14Glycine (3TMS)0.1700470.008320.1680720.005171.010.7284
15Nonanoic acid (C9)0.0046850.000260.0087840.000850.530.0022
16Alanine0.0055160.000610.0045010.000261.230.3538
17Meso-erythritol0.037540.017060.0151390.002052.480.1049
18Aspartic acid0.0566140.004490.057840.002650.980.4847
19Methionine0.049340.003270.0571110.002760.860.0056
20Trans-4-hydroxy-l-proline0.0328740.003430.0281490.002571.170.3963
21Pyrogallol0.0010750.000250.0015040.000340.710.4112
22Creatinine0.0085120.000880.0103860.000470.820.0002
23Glutamic acid0.209680.032760.1581330.018831.330.3818
24Phenylalanine0.1941450.01060.2109240.014520.920.4062
25Arabinose0.0039060.000390.0022380.000171.75<.0001
26Lauric acid0.0107970.000790.0136770.001130.790.1011
27Ribulose0.0049070.001930.0035410.000211.390.0147
28Asparagine0.0332920.001680.038320.001450.870.0162
29Xylitol0.0035820.000560.0047660.00080.750.8986
30Arabitol0.0671930.01830.0702070.013950.960.2895
31Glutamine0.6874850.040210.7957860.025930.860.0072
32O-phosphoethanolamine0.0005490.000020.0007150.000080.770.0009
33Glycyl-Glycine_10.000810.000090.001070.000060.760.0063
34Citric acid + isocitric acid0.1880290.011970.1701730.007931.100.4366
35Ornithine0.031550.002050.0283590.001211.110.5828
361,5-Anhydro-d-glucitol0.1497950.013490.2744260.014430.55<.0001
37Glucose_11.3317260.091641.2667380.103051.050.3676
38Mannose_21.4636410.079251.5013080.067220.970.7684
39Lysine (4TMS)0.1242830.005870.1602920.009430.780.0005
40Histidine0.0199620.000950.0286030.001910.70<.0001
41Glucuronate_10.0166760.008160.0036480.000254.570.1011
42Tyrosine0.3615960.020230.4316450.027830.840.0067
43Inositol0.0901730.006830.0798170.003341.130.5413
44Uric acid0.2356010.012390.2785960.011970.850.0170
45Cysteine + cystine0.0448560.002860.0437950.00321.020.6508

NOTE: The serum levels of each metabolite were normalized to the peak intensity of the internal standard; that is, 2-isopropylmalic acid.

  • aFold induction values were calculated from the PC to HV ratio.

  • bP values were calculated using the Wilcoxon rank-sum test.