Table 2.

Plasma concentration and diagnostic characteristics of the 3 kidney tumor markers and composite 3 markers

MarkersNNMTLCP1NM23ANNMT, LCP1, NM23A logisticNNMT, LCP1, NM23A Score
Cut-point for Scoring>147>12,974>1,230regression>1
Training Group (n = 189)
Concentration (pg/mL)Median (range lower and upper 95% CI)
 Control group (n = 102)68 (54.8–83.2)10,384 (10.181.1–10.644.1)780 (661.0–878.3)
 Kidney cancer (n = 87)420 (332.6–511.8)13.789 (13.382.5–14,313.8)3,442 (2,953.6–4,488.2)
AUC (95%CI)0.900 (0.848–0.938)0.890 (0.836–0.931)0.876 (0.820–0.919)0.904 (0.853–0.942)0.921 (0.873–0.955)
Sensitivity, % (95%CI)95.5 (88.8–98.7)90.9 (82.9–96.0)93.2 (85.7–97.5)90.9 (82.9–96.0)94.3 (87.2–98.1)
Specificity, % (95%CI)78.43 (69.2–86.0)82.4 (73.6–89.2)76.5 (67.0–84.3)84.3 (75.8–90.8)90.2 (82.7–95.2)
Specificity = 90%, Sensitivity, % (95% CI)59.1 (29.9–79.6)73.9 (33.0–88.6)54.6 (30.7–73.9)71.6 (42.1–89.8)94.4 (51.2–99.1)
Test Group (n = 100)
AUC (95%CI)0.952 (0.889–0.985)0.919 (0.847–0.964)0.914 (0.841–0.961)0.967 (0.910–0.992)0.954 (0.892–0.986)
Specificity = 90%, Sensitivity, % (95% CI)84.6 (26.9–100.0)88.5 (15.4–96.2)80.8 (0.00–96.2)96.2 (69.6–100.00)100 (28.1–100.0)
Combined total group
AUC (95%CI)0.919 (0.875–0.943)0.895 (0.853–0.927)0.87 (0.826–0.907)0.922 (0.871–0.941)0.932 (0.896–0.958)
Sensitivity, % (95%CI)93.9 (87.8–97.5)90.4 (83.4–95.1)92.1 (85.5–96.3)91.2 (84.5–95.7)95.6 (90. 1–98.6)
Specificity, % (95%CI)83.4 (77.1–88.6)83.4 (77.1–88.6)75.4 (68.4–81.6)83.4 (77.1–88.6)90.9 (85.6–94.7)
+PV, % (95%CI)78.7 (70.8–85.2)78.0 (70.0–84.8)70.9 (62.9–78.1)78.2 (70.2–84.9)87.2 (80.0–92.5)
−PV, % (95%CI)95.4 (90.8–98.1)93.0 (87.8–96.5)93.6 (88.2–97.0)93.6 (88.5–96.9)97.0 (93.0–99.0)
Specificity = 90%, Sensitivity, % (95% CI)71.9 (41.3–89.5)73.7 (37.7–86.8)47.4 (27.2–69.3)76.3 (53.5–87.7)95.7 (59.8–99.5)