Table 2.

Gene and SNP information for included TGF-β signaling pathway genes among women in Shanghai

GenomicGeneSNPS inSNPs genotypedGenetic variation
TGFβ pathway geneslocationspan, kbHapMapaAllMAF ≥ 5%coverage (%)b
Ligands
 TGFB119q13.123.216141393.8
 TGFB21q4195.1106442981.1
 TGFB314q2423.11913668.4
Receptors
 TGFBR19q2249.149241691.8
 TGFBR23p2287.61181028097.5
 TGFBR31p33-p32203.72981128681.5
Cofactors
 SMAD218q2198.1874537100.0
 SMAD315q21-22129.3170765177.6
 SMAD418q21.149.52510892.0
 SMAD718q21.130.92717648.1
 SARA (ZFYVE9)1p32.3204.35022988.0
  • aSNPs with a MAF ≥ 5% in HapMap (v2 R24), Han Chinese (CHB) data, ± 10 kb for each gene.

  • bCoverage of HapMap CHB SNPs by our genotyped SNPs for r2 = 0.8, using a pairwise tagging approach in Tagger.