Table 2.

Expression levels of 3 genes surrounding the case-associated haplotype in healthy dogs showing all 3 genotypes

GenotypeaAmountbIncreasecPd
CDKN2A20.00257716.89880.0173
10.0013348.7482>0.05
00.0001531
CDKN2B20.0006973.9760.0087
10.0005182.9567>0.05
00.0001751
MTAP20.0097581.2412>0.05
10.0090281.1484>0.05
00.0078621
  • aThe genotype is the number of copies of the case associated (CA) haplotype with 2 = homozygous for the CA haplotype, 1 = heterozygous, and 0 = no copies of the CA haplotype.

  • bThe amount of transcript is relative to the amount of B2M transcript and normalized by comparison with expression in testes.

  • cIncrease in expression of each gene in individuals carrying the CA haplotype compared with those without.

  • dP values were calculated by Wilcoxon rank sum on the distribution of relative expression levels within each genotype group.