Table 4.

Association of TGFBR2 rs1078985 and breast cancer risk by tumor stage, the SBCGS

Stage 0 or IStage IIStage III or IVTotala
NcasesOR (95% CI)NcasesOR (95% CI)NcasesOR (95% CI)NcasesOR (95% CI)Pd
TGFBR2 rs1078985
AA1,6611.00 (reference)2,5021.00 (reference)4951.00 (reference)5,0791.00 (reference)0.7738
AG5680.91 (0.82–1.02)8230.87 (0.79–0.96)1810.98 (0.82–1.17)1,7040.89 (0.82–0.96)
GG450.72 (0.52–1.01)720.76 (0.58–1.01)150.81 (0.47–1.38)1440.75 (0.60–0.94)
Pb0.01980.00110.52940.0003
AA/AG2,2291.00 (reference)3,3251.00 (reference)6761.00 (reference)6,7831.00 (reference)0.6869
GG450.74 (0.53–1.03)720.79 (0.60–1.05)150.81 (0.48–1.39)1440.77 (0.62–0.97)
Pc0.07690.10260.45020.0263

NOTE: Bold values denote significance at P ≤ 0.05.

  • aIncludes 565 women without information on tumor stage.

  • bPtrend.

  • cP value for recessive association.

  • dP value for heterogeneity test.