Table 1.

Per-allele relative risks of associated SNPs considered in this study

SNPBandGeneMAFUnselected casesFamilial casesBilateral cases
rs112494331p110.391.16 (1.09–1.24)a1.08 (1.02–1.15)1.22 (1.09–1.35)
rs133870422q350.491.12 (1.09–1.15)b1.21 (1.14–1.29)1.09 (0.97–1.21)
rs49737683p22SLC4A70.461.11 (1.08–1.13)c1.16 (1.10–1.24)1.11 (0.99–1.23)
rs109416795p120.251.19 (1.11–1.28)d1.11 (1.04–1.19)g1.29 (1.15–1.43)
rs8893125q11MAP3K10.381.12 (1.08–1.16)e1.22 (1.14–1.30)1.11 (1.01–1.21)
rs20462106q250.341.15 (1.03–1.28)f1.15 (1.08–1.22)g1.12 (0.99–1.25)
rs298158210q25FGFR20.381.26 (1.22–1.29)e1.43 (1.35–1.53)1.39 (1.29–1.49)
rs381719811p15LSP10.31.07 (1.04–1.11)e1.12 (1.05–1.19)1.10 (1.00–1.20)
rs380366216q12TOX30.251.19 (1.15–1.23)e1.30 (1.22–1.39)1.41 (1.30–1.52)
rs650495017q22COX110.270.95 (0.92–0.97)c0.92 (0.86–0.99)g0.93 (0.79–1.07)

Estimates for unselected cases are taken from

  • aref. (19),

  • bref. (14),

  • cref. (15),

  • dref. (17),

  • eref. (16), and

  • fref. (18). Estimates for familial cases are taken from ref. (6). Estimates for bilateral cases are taken from this study (see Methods).

  • gRelative risk for a proximal SNP in LD (r2 > 0.75) with the lead SNP.

  • Abbeviation: MAF, minor allele frequency.