Table 2.

Prior distribution of MAF and SD of log relative risk

MAF (%)ENCODE frequency (%)SD of log RR
0–5461.21
5–10130.84
10–15100.61
15–2060.46
20–2550.36
25–3050.3
30–3540.25
35–4040.23
40–4540.21
45–5030.2

NOTE: “ENCODE frequency” gives the proportion of variants in the ENCODE regions having MAF in the stated range. “SD of log RR” gives the SD of the log relative risk for SNPs according to the model of Spencer and colleagues (13).

Abbreviations: RR, relative risk; SD, standard deviation.