Table 4.

Multivariable-adjusted RR and 95% CI of endometrial cancer according to category of cumulative average coffee intake stratified by covariates in the NHS cohorta

Coffee intake, RR (95% CI)
CovariatesNo. of cases<1 cup/d1 cup/d2–3 cups/d≥ 4 cups/dPtrendPinteraction
BMI, kg/m2
 <252191.001.03 (0.65–1.62)1.17 (0.80–1.69)0.93 (0.58–1.49)0.92
 25–29.92071.001.05 (0.68–1.62)0.98 (0.67–1.42)0.78 (0.48–1.26)0.300.22
 302461.001.16 (0.81–1.66)0.77 (0.55–1.08)0.62 (0.38–1.01)0.02
Smoking status
 Never3501.001.06 (0.79–1.44)0.95 (0.73–1.25)0.87 (0.59–1.29)0.440.33
 Ever3221.001.00 (0.69–1.44)0.89 (0.65–1.22)0.65 (0.44–0.95)0.02
Menopausal status
 Premenopausal941.001.35 (0.70–2.61)1.16 (0.66–2.03)1.02 (0.52–2.01)0.990.81
 Postmenopausal5461.001.02 (0.79–1.32)0.92 (0.73–1.15)0.74 (0.55–1.00)0.04
 Postmenopausal -BMI ≥253731.001.05 (0.78–1.41)0.84 (0.64–1.10)0.67 (0.46–0.98)0.02
Postmenopausal hormone useb
 Never/Past use3741.000.96 (0.71–1.30)0.84 (0.64–1.10)0.69 (0.48–1.00)0.030.24
 Current use1721.001.13 (0.68–1.87)1.11 (0.72–1.71)0.87 (0.50–1.54)0.68
  • aAdjusted for the same covariates for coffee analyses in Table 2 (BMI as a continuous variable was kept in the models for <25, 25 to 29.9, and ≥30 kg/m2. Pack-years of smoking as a categorical variable was kept in the model for past or current smokers. Past hormone use variable was kept in the model for never/past hormone users. Type of postmenopausal hormone was kept in the model for current hormone users).

  • bAmong postmenopausal women only.