Table 4.

Combined sensitivity and specificity for investigated parameters in detection of bladder cancer, especially superficial, low-grade, bilharzial bladder cancer, and SCC

Investigated parametersBladder CancerNon-muscle invasion (superficial bladder cancer)Low grade Bladder cancerBilharzial Bladder cancerSCC
Sens.%Spec., %Sens., %Spec., %Sens., %Spec., %Sens., %Spec., %Sens., %Spec., %
Urine cytology43.310048.910045.310036.810026.3100
Urinary RARβ2 promoter hypermethylation62.887.960.987.96487.950.987.962.387.9
Urinary APC promoter hypermethylation59.59862.69858.89850.69873.698
Urine cytology + Urinary RARβ2 promoter hypermethylation79.189.480.489.481.489.46689.478.989.4
Urine cytology + Urinary APC promoter hypermethylation75.59880.49874.49866.39873.798
Urinary RARβ2 promoter hypermethylation + Urinary APC promoter hypermethylation87.397.68897.687.297.677.597.689.597.6
Urine cytology + Urinary RARβ2 promoter hypermethylation + Urinary APC promoter hypermethylation91.897.693.597.691.997.680.997.689.597.6