Table 3

Relationship between plasma 1,25(OH)2D and 25(OH)D and distal colorectal adenoma by site and size/histology among 326 matched pairs nested in the Nurses’ Health Study, 1989–1996

QuartileaP-trendb
1234
Rectumc
1,25(OH)2D
No. cases/controls16/1718/1413/1618/18
ORd1.001.350.581.060.9
95% CI0.41–4.430.16–2.090.30–3.73
25(OH)D
No. cases/controls24/187/1610/1324/18
ORd1.000.380.341.590.9
95% CI0.12–1.190.08–1.420.50–5.03
Distal colonc
1,25(OH)2D
No. cases/controls81/6353/7071/6456/64
ORd1.000.510.780.600.2
95% CI0.30–0.860.45–1.340.34–1.04
25(OH)D
No. cases/controls79/6455/6451/6976/64
ORd1.000.710.601.021.0
95% CI0.43–1.180.35–1.020.60–1.73
Large, villous, or tubulovillousc
1,25(OH)2D
No. cases/controls41/3136/3835/3230/41
ORd1.000.620.730.480.1
95% CI0.29–1.320.33–1.610.21–1.08
25(OH)D
No. cases/controls45/3624/3726/3547/34
ORd1.000.540.671.300.9
95% CI0.25–1.160.31–1.440.59–2.86
Small and tubularc
1,25(OH)2D
No. cases/controls51/4533/4447/4743/38
ORd1.000.630.860.940.6
95% CI0.32–1.240.44–1.680.48–1.86
25(OH)D
No. cases/controls55/4336/4033/4550/46
ORd1.000.640.540.930.6
95% CI0.34–1.190.27–1.070.49–1.75
  • a Quartile medians: 22.3, 29.0, 33.9, and 40.9 pg/ml for 1,25(OH)2D and 16.3, 22.6, 28.3, 38.0 ng/ml for 25(OH)D.

  • b Test for trend calculated by entering a continuous term in the conditional logistic regression model.

  • c Numbers do not sum to total because of missing information on site, size, or histology.

  • d OR and 95% CI were estimated from conditional logistic regression model after adjusting for mean values (1980–1990) for body mass index, physical activity, aspirin use, cigarette pack-years smoked, alcohol consumption, intake of red meat and methionine, 1980 folic acid intake, and 1990 postmenopausal hormone use.