Table 2

Relationship between plasma 1,25(OH)2D and 25(OH)D and distal colorectal adenoma among 326 matched pairs nested in the Nurses’ Health Study, 1989–1996

QuartileP-trenda
1234
Median 1,25(OH)2D (pg/ml)22.329.033.940.9
No. of cases97718474
No. of controls80848082
ORb1.000.680.830.710.3
95% CI0.44–1.060.53–1.310.44–1.13
ORc1.000.640.800.710.4
95% CI0.41–1.020.50–1.300.43–1.15
Median 25(OH)D (ng/ml)16.322.628.338.0
No. of cases1036261100
No. of controls82808282
ORb1.000.630.590.960.7
95% CI0.41–0.970.38–0.930.63–1.47
ORc1.000.640.581.041.0
95% CI0.41–1.000.36–0.950.66–1.66
  • a Test for trend calculated by entering a continuous term in the conditional logistic regression model.

  • b OR and 95% CI estimated from conditional logistic regression model.

  • c OR and 95% CI estimated from conditional logistic regression model after adjusting for mean values (1980–1990) for body mass index, physical activity, aspirin use, cigarette pack-years smoked, alcohol consumption, intake of red meat and methionine, 1980 folic acid intake, and 1990 postmenopausal hormone use.