Table 5

Combined effects of folate, methionine, and alcohol on risk of colon cancer

FolateaMethionineAllsubjectsNon-alcohol drinkersAlcohol drinkers
CC/CT, OR (95% CI)bTT, OR (95% CI)CC/CT, OR (95% CI)TT, OR (95% CI)CC/CT, OR (95% CI)TT, OR (95% CI)
LowLow1.01.0 (0.5–2.3)1.00.9 (0.2–4.0)1.01.2 (0.4–3.1)
Intermediate0.9 (0.7–1.3)0.7 (0.4–1.2)1.0 (0.6–1.6)1.1 (0.5–2.4)0.9 (0.6–1.3)0.4 (0.1–0.9)
High1.0 (0.7–1.6)0.9 (0.2–2.8)1.1 (0.6–2.1)0.5 (0.1–2.7)0.9 (0.5–1.8)c
HighLow0.9 (0.6–1.4)0.7 (0.3–1.7)1.0 (0.5–1.8)0.7 (0.2–2.3)0.8 (0.4–1.5)0.5 (0.1–2.5)
Intermediate0.6 (0.4–0.9)0.6 (0.3–1.0)0.6 (0.4–1.1)0.8 (0.3–1.8)0.6 (0.4–1.1)0.4 (0.2–1.0)
High0.8 (0.5–1.2)0.3 (0.1–0.9)0.7 (0.4–1.2)0.4 (0.1–1.1)0.9 (0.5–1.7)c
  • a High folate was defined as >205 μg per 1000 calories; high methionine was defined as >1.0 g per 1000 calories; low folate was defined as ≤135 μg per 1000 calories; low methionine was defined as <0.75 g per 1000 calories; intermediate levels fell between these values.

  • b Nutrients were evaluated as nutrients per 1000 kcal and adjusted for sex, age, BMI, long-term vigorous physical activity, usual number of cigarettes smoked per day, total energy intake, and dietary fiber.

  • c Too few numbers in cell to estimate associations.