Table 4

Associations between nutrients and MTHFR status by age at time of diagnosis

MTHFR genotype≤60 years, OR (95% CI)a>60 years, OR (95% CI)
LowIntermediateHighLowIntermediateHigh
Folate
CC1.00.8 (0.5–1.3)0.7 (0.3–1.3)1.00.9 (0.6–1.2)0.9 (0.6–1.4)
CT1.0 (0.6–1.6)0.7 (0.4–1.1)0.5 (0.3–1.1)1.0 (0.7–1.4)1.0 (0.8–1.4)0.9 (0.6–1.3)
TT1.1 (0.5–2.7)1.0 (0.4–1.9)0.6 (0.2–1.7)0.7 (0.4–1.2)0.8 (0.5–1.3)0.6 (0.4–1.1)
Vitamin B6
CC1.00.7 (0.5–1.2)0.6 (0.3–1.2)1.00.8 (0.6–1.1)1.0 (0.7–1.5)
CT0.7 (0.5–1.2)0.7 (0.4–1.1)0.8 (0.4–1.7)1.0 (0.7–1.4)1.0 (0.7–1.4)0.9 (0.6–1.3)
TT0.6 (0.2–1.3)1.0 (0.5–2.0)1.1 (0.4–2.9)0.9 (0.5–1.7)0.8 (0.5–1.2)0.5 (0.3–0.9)
Vitamin B12
CC1.00.9 (0.5–1.5)0.9 (0.5–1.5)1.01.1 (0.8–1.5)1.1 (0.7–1.5)
CT1.0 (0.6–1.8)0.8 (0.5–1.3)0.7 (0.4–1.3)1.2 (0.8–1.7)1.3 (0.9–1.7)0.9 (0.6–1.3)
TT1.6 (0.6–4.2)0.7 (0.4–1.6)1.0 (0.4–2.6)1.0 (0.5–1.8)0.9 (0.6–1.3)0.6 (0.4–1.2)
  • a Nutrients evaluated as nutrients per 1000 kcal and adjusted for sex, age, BMI, long-term vigorous physical activity, usual number of cigarettes smoked per day, total energy intake, and dietary fiber.