Table 3

Associations between nutrients and MTHFR status by tumor site

MTHFR genotypeProximal, OR (95% CI)aDistal, OR (95% CI)
LowIntermediateHighLowIntermediateHigh
Folate
CC1.00.8 (0.6–1.1)0.9 (0.6–1.4)1.00.9 (0.6–1.2)0.8 (0.5–1.2)
CT0.9 (0.7–1.3)0.9 (0.6–1.2)0.8 (0.6–1.3)1.1 (0.8–1.6)1.0 (0.7–1.3)0.7 (0.5–1.2)
TT0.7 (0.4–1.3)0.8 (0.5–1.4)0.5 (0.2–0.9)0.9 (0.5–1.5)0.9 (0.5–1.4)0.8 (0.5–1.5)
Vitamin B6
CC1.00.8 (0.6–1.1)1.1 (0.7–1.6)1.00.7 (0.5–1.0)0.8 (0.5–1.1)
CT1.0 (0.7–1.4)0.8 (0.6–1.2)1.0 (0.6–1.4)0.8 (0.6–1.2)0.9 (0.7–1.3)0.8 (0.5–1.2)
TT0.8 (0.4–1.5)0.8 (0.5–1.3)0.5 (0.3–0.9)0.8 (0.4–1.4)0.8 (0.5–1.3)0.7 (0.4–1.3)
Vitamin B12
CC1.01.3 (0.9–1.8)1.2 (0.8–1.8)1.00.8 (0.6–1.2)0.9 (0.6–1.3)
CT1.3 (0.9–1.8)1.3 (0.9–1.8)1.0 (0.7–1.5)1.0 (0.7–1.5)1.0 (0.7–1.4)0.8 (0.6–1.2)
TT1.1 (0.6–2.2)1.0 (0.6–1.6)0.6 (0.3–1.3)1.1 (0.6–2.1)0.8 (0.5–1.2)0.9 (0.5–1.6)
  • a Nutrients were evaluated as nutrients per 1000 kcal and adjusted for sex, age, BMI, long-term vigorous physical activity, usual number of cigarettes smoked per day, total energy intake, and dietary fiber.