Table 2

Associations between nutrients and MTHFR status in men and women

MTHFR genotypeOR (95% CI)a
LowIntermediateHigh
Folateb
CC1.00.8 (0.7–1.1)0.8 (0.6–1.2)
CT1.0 (0.8–1.3)0.9 (0.7–1.2)0.8 (0.6–1.1)
TT0.8 (0.5–1.3)0.8 (0.6–1.2)0.6 (0.4–1.0)
Vitamin B6
CC1.00.8 (0.6–1.0)0.9 (0.7–1.3)
CT0.9 (0.7–1.2)0.9 (0.7–1.2)0.9 (0.6–1.2)
TT0.8 (0.5–1.3)0.8 (0.6–1.2)0.6 (0.4–1.0)
Vitamin B12
CC1.01.1 (0.8–1.4)1.0 (0.8–1.4)
CT1.1 (0.7–1.9)1.1 (0.9–1.4)0.9 (0.6–1.2)
TT1.2 (0.7–1.9)0.9 (0.6–1.2)0.7 (0.5–1.2)
Methionine
CC1.00.9 (0.7–1.2)0.8 (0.6–1.0)
CT1.0 (0.7–1.3)0.9 (0.7–1.2)0.9 (0.6–1.2)
TT0.9 (0.5–1.4)0.7 (0.5–1.0)0.8 (0.5–1.3)
Alcohol
CC1.00.9 (0.7–1.2)0.8 (0.6–1.1)
CT0.9 (0.7–1.1)1.0 (0.8–1.3)1.2 (0.9–1.6)
TT1.0 (0.7–1.4)0.5 (0.3–0.8)1.0 (0.6–1.6)
Multivitamin supplementc
CC1.01.1 (0.9–1.3)
CT1.0 (0.8–1.2)1.1 (0.9–1.4)
TT0.9 (0.7–1.2)0.9 (0.6–1.3)
  • a Nutrients were evaluated as nutrients per 1000 kcal and adjusted for sex, age, BMI, long-term vigorous physical activity, usual number of cigarettes smoked per day, total energy intake, and dietary fiber.

  • b Cut-off points for men were: folate, 126/197; vitamin B6, 0.8/1.2; vitamin B12, 1.9/3.31; methionine, 0.74/1.0; alcohol, 1/20. Cut-off points for women were: folate, 141/214; vitamin B6, 0.85/1.21; vitamin B12, 1.88/3.31; methionine, 0.75/1.0; alcohol, 1/20.

  • c Includes any reported use of multivitamin supplements or any supplement that contains folate or B vitamins during the referent year. Low, used no multivitamin supplement; High, used multivitamin supplement.