Table 1

Associations between MTHFR and colon cancer

MTHFR genotypeMenWomenAll subjects
Cases (n)Controls (n)OR (95% CI)aCases (n)Controls (n)OR (95% CI)Cases (n)Controls (n)OR (95% CI)
CC 3724351.03013921.06738271.0
CT 3784231.0 (0.9–1.3)2773591.0 (0.8–1.3)6557871.0 (0.9–1.2)
TT 741090.8 (0.6–1.1)65980.9 (0.6–1.2)1392070.9 (0.7–1.1)
Distal tumors
CC1754351.01413921.03168271.0
CT1894231.1 (0.9–1.5)1303591.0 (0.8–1.3)3297871.1 (0.9–1.3)
TT411091.0 (0.7–1.5)32980.9 (0.6–1.5)732071.0 (0.7–1.3)
Proximal tumors
CC1854351.01543921.03398371.0
CT1774231.0 (0.8–1.3)1423591.0 (0.8–1.4)3197871.0 (0.8–1.2)
TT331090.7 (0.5–1.1)31980.8 (0.5–1.3)642070.8 (0.6–1.1)
  • a Adjusted for age, BMI, long-term vigorous physical activity, energy intake, dietary fiber, and usual number of cigarettes smoked.