Table 1

LO inhibition: Potential chemopreventive mechanisms

Chemopreventive mechanismSpecific activity
Antiproliferation12-LO inhibition
 Modulate signal transduction (5) ↓PKC (5 6 7 , 91 , 213) , cAMP (214 , 215) , tyrosine kinase (216 , 217)
 Modulate growth factor activity (8 9 10 , 71 , 119 , 218 , 219) ↓EGF, FGF, PDGF, tumor necrosis factor, GRP, K-ras, c-myc, int-2
 Inhibit oncogene expression (94 , 137 , 220)
Apoptosis induction (155 , 221 , 222)5-LO, 12-LO inhibition
 Antioxidant activity (145) ↓Free radical production
 Block metabolic activation (72 , 73)
Angiogenesis inhibition12-LO inhibition
 Inhibit membrane degradation (13) ↓Cathepsin B
 Decrease tumor cell adhesion (7 , 9) ↓Endothelial cell growth
 Decrease tumor cell motility (223)
 Inhibit metastasis (2 , 4)
Antiinflammatory5-LO/FLAP inhibition
 Prevent tissue damage (224 225 226) ↓PMN activation
 Modulate immune response (227) ↓T-lymphocyte activation