Table 6

Associations between MTHFR and high- and low-risk diets as determined by combined levels of folate, methionine, and alcohola

MTHFR genotypeOR (95% CI)b
High riskIntermediate riskLow risk
CC/TT cases/controls109/961180/144939/64
TT cases/controls11/10121/1797/18
All subjects
CC/CT1.00.8 (0.6–1.0)0.6 (0.4–1.0)
TT1.0 (0.4–2.4)0.7 (0.5–1.0)0.4 (0.1–0.9)
Subjects ≤60 years
CC/CT1.00.7 (0.4–1.2)0.6 (0.2–1.9)
TT0.6 (0.1–2.6)0.8 (0.4–1.7)0.2 (0.02–1.8)
Subjects ≤60 years
CC/CT1.00.8 (0.5–1.0)0.6 (0.3–1.0)
TT1.3 (0.4–4.5)0.6 (0.4–0.9)0.4 (0.2–1.2)
  • a Low risk was defined as folate ≥195 μg per 1000 calories, methionine, ≥1.0 g per 1000 calories and non-alcoholic beverage drinker. High risk was defined as folate ≤140 μg per 1000 calories, methionine ≤0.80 g per 1000 calories, and alcohol >10 g per day. Values between those for low and high are considered intermediate.

  • b Nutrients were evaluated as nutrients per 1000 kcal and adjusted for sex and age.