Table 3

Average urinary excretion of nicotine and metabolites as percentage of nicotine and seven quantified metabolitesa

MetabolitePercentage ± SDRange (%)
Nicotine7.92 ± 4.621–15
Nicotine-Gluc2.58 ± 2.110–7
Cotinine14.8 ± 5.898–27
Cotinine-Gluc12.1 ± 5.951–17
trans-3′-Hydroxycotinine42.4 ± 12.827–71
trans-3′-Hydroxycotinine-Gluc10.3 ± 7.640 –23
Keto acid1.75 ± 0.621–3
Hydroxy acid8.33 ± 1.725–11
  • a Levels of metabolites on a single baseline day for 12 subjects.