Table 3.

Odds Ratios and Confidence Intervals for risk of breast cancer associated with plasma level of Q10 and stratified by menopausal status, a nested case-control study within the SWHS, 1997 to 2006

Case-control pairsOR (95% CI) by quintile of plasma concentration of CoQ10
Q1aQ2aQ3aQ4aQ5aPtrend
All women
3401.55 (0.97–2.48)1.14 (0.72–1.80)1.00 (reference)1.11 (0.71–1.74)0.97 (0.60–1.60)0.09
Women with cases diagnosed > 1 y after blood draw
3031.90 (1.14–3.16)1.41 (0.87–2.30)1.00 (reference)1.15 (0.71–1.87)1.13 (0.66–1.91)0.03
OR (95% CI) by menopausal status and quartile of CoQ10
Q1bQ2bQ3bQ4bPtrend
Premenopausal womenc
All1711.62 (0.91–2.89)1.38 (0.78–2.44)1.00 (reference)1.15 (0.65–2.02)0.16
>1 y1521.89 (1.01–3.54)1.70 (0.91–3.16)1.00 (reference)1.25 (0.68–2.32)0.09
Postmenopausal womenc
All1691.35 (0.79–2.28)1.04 (0.58–1.88)1.00 (reference)0.96 (0.52–1.79)0.24
>1 y1511.71 (0.95–3.09)1.14 (0.60–2.15)1.00 (reference)1.15 (0.59–2.23)0.14
  • NOTE: A conditional logistic regression model was used whereby controls were matched to the index case by age, menopausal status at baseline, date of sample collection, time of sample collection, time interval after the last meal, and recent antibiotic use and additionally adjusted for age at 1st live birth (continuous).

    a20th, 40th, 60th, and 80th percentiles were 429.0, 536.0, 629.0, and 796.0 ng/mL, respectively, for all subjects.

  • b25th, 50th, and 75th percentiles were 417, 537, and 665 ng/mL, respectively, for premenopausal women; and 517.5, 633, and 825 ng/mL, respectively, for postmenopausal women.

  • cPinteractions = 0.40.