Table 3.

Plasma nicotine metabolites by UGT2B10 genotype (study 1)

AnalyteWild-type (n = 95) mean (SD)Asp67Tyr* (n = 20) mean (SD)Range
Free cotinine (nmol/mL)1.09 (0.49)1.31 (0.40)0.19-2.75
Cotinine glucuronide (nmol/mL)0.15 (0.14)0.13 (0.14)0.00-0.54
Percent cotinine glucuronide11.3 (9.7)8.72 (9.0)0.0-36.4
Total trans-3′-hydroxycotinine (nmol/mL)0.39 (0.32)0.46 (0.24)0.04-1.92
Total trans-3′-hydroxycotinine to free cotinine0.38 (0.28)0.37 (0.18)0.07-1.29
  • *UGT2B10 heterozygous individuals.

  • P = 0.03.

  • P = 0.04.