Table 1.

Distribution of urinary metabolites by genotype as a molar percentage of nicotine and its metabolites

AnalyteWild-type mean percent (SD), n = 263UGT2B10 Asp67Tyr* mean percent (SD), n = 62P
Nicotine11.8 (9.5)11.8 (8.5)0.75
Nicotine glucuronide6.1 (5.1)4.2 (3.3)0.003
Cotinine13.4 (6.8)16.0 (7.4)0.003
Cotinine glucuronide24.2 (10.7)17.6 (8.0)<0.0001
Trans-3′-hydroxycotinine44.3 (16.7)51.1 (14.6)0.001
Percent nicotine glucuronidation38.2 (23.6)29.5 (18.8)0.007
Percent cotinine glucuronidation62.8 (18.2)51.3 (18.5)<0.0001

NOTE: Molar percentage = (analyte/∑ nicotine + cotinine + trans-3′-hydroxycotinine + glucuronides) × 100.

  • *UGT2B10 Asp67Tyr heterozygous individuals.

  • Percent of analyte excreted as its glucuronide conjugate.