Table 3.

Incidence RRs and 95% CIs for talc use and endometrial cancer risk among postmenopausal women in the NHS

No. of casesPerson-yearsAge-adjusted RR (95% CI)Multivariate RR* (95% CI)
Ever perineal talc use
    No287461,3811.001.00
    Yes242281,9581.38 (1.16-1.64)1.21 (1.02-1.44)
Frequency of perineal talc use
    No use287461,3811.001.00
    Less than once a week5776,8451.22 (0.91-1.62)1.09 (0.81-1.45)
    One to six times a week8797,7931.40 (1.10-1.79)1.28 (1.00-1.63)
    Daily98107,3201.49 (1.18-1.87)1.24 (0.98-1.56)
    P trend<0.0010.04
Regular perineal talc use (at least once a week)
    No344538,2271.001.00
    Yes185205,1131.40 (1.17-1.68)1.24 (1.03-1.49)
Sanitary napkin talc use
    No403587,3171.001.00
    Yes6794,2331.04 (0.80-1.35)0.98 (0.75-1.27)
  • *Adjusted for age, parity (0, 1, 2, 3, 4+), age at last birth (nulliparous, <30, 30-34, 35-39, ≥40), age at menarche (≤11, 12, 13, ≥14), age at menopause (<45, 45-49, 50-54, ≥55), OC duration (never, ≤12 mo, 13-36 mo, 37-72 mo, >72 mo), PMH duration (never, past <5 y, past 5+ y, current <5 y, current 5+ y), BMI (continuous), smoking pack-years (0, 1-20, 21-40, 40+), diabetes (no, yes), and family history of uterine cancer (no, yes).

  • P trend for categories of frequency of perineal talc use weighted as 0, 2, 15.5, and 30 d of use per month.