Table 2.

Incidence RRs and 95% CIs for ever and regular talc use and endometrial cancer risk among all women and stratified by menopausal status in the NHS

WomenEver perineal talc useRegular perineal talc use (at least once a week)
NoYesNoYes
All women
    Cases334265397202
    Person-years687,327420,106806,391301,041
    RR (95% CI)*1.001.13 (0.96-1.33)1.001.17 (0.99-1.40)
Postmenopausal
    Cases287242344185
    Person-years461,381281,958538,227205,113
    RR (95% CI)*1.001.21 (1.02-1.44)1.001.24 (1.03-1.48)
Premenopausal
    Cases47235317
    Person-years204,180125,414242,41987,176
    RR (95% CI)1.000.69 (0.40-1.19)1.000.77 (0.42-1.39)
P interaction0.020.07
  • *Adjusted for age, parity (0, 1, 2, 3, 4+), age at last birth (nulliparous, <30, 30-34, 35-39, ≥40), age at menarche (≤11, 12, 13, ≥14), age at menopause (premenopausal, <45, 45-49, 50-54, ≥55), OC duration (never, ≤12 mo, 13-36 mo, 37-72 mo, >72 mo), PMH duration (premenopausal/never, past <5 y, past 5+ years, current <5 y, current 5+ y), BMI (continuous), smoking pack-years (0, 1-20, 21-40, 40+), diabetes (no, yes), and family history of uterine cancer (no, yes); also adjusted for menopausal status (premenopausal, postmenopausal) among all women only.

  • Adjusted for age, parity (0, 1, 2, 3, 4+), age at last birth (nulliparous, <30, 30-34, 35-39, ≥40), age at menarche (≤11, 12, 13, ≥14), OC duration (never, ≤12 mo, 13-36 mo, 37-72 mo, >72 mo), BMI (continuous), smoking pack-years (0, 1-20, 21-40, 40+), diabetes (no, yes), and family history of uterine cancer (no, yes).

  • Wald test for interaction term between talc use and menopausal status.