Variable | Relative risk (95% confidence interval) | P |
---|---|---|

Age at diagnosis (n = 279) | 1.00 (0.97-1.03) | 0.881 |

Clinical stage (n = 278)^{*} | 1.40 (0.93-2.11) | 0.114 |

Pathologic stage (n = 279)^{†} | 2.59 (1.75-3.84) | <0.0001 |

Preoperative PSA (n = 263)^{‡} | 1.78 (1.22-2.62) | 0.003 |

Gleason score (n = 279)^{§} | 2.58 (1.76-3.80) | <0.0001 |

Margins (n = 279) | 1.82 (1.24-2.68) | 0.002 |

Seminal vesicle involvement (n = 279) | 2.24 (1.52-3.30) | <0.0001 |

Extracapsular extension (n = 279) | 2.30 (1.56-3.39) | <0.0001 |

Ki67 (n = 277)^{∥} | 1.08 (1.01-1.15) | 0.011 |

Ki67 (n = 277)^{¶} | 1.94 (1.22-3.07) | 0.005 |

H3K18Ac POS (n = 279)^{**} | 1.01 (1.00-1.02) | 0.043 |

H3K18Ac POS (n = 279)^{††} | 1.73 (1.13-2.64) | 0.012 |

H3K18Ac MIOD (n = 279)^{‡‡} | 1.02 (0.99-1.04) | 0.167 |

H3K18Ac MOD (n = 279)^{§§} | 1.00 (0.98-1.02) | 0.734 |

H3K4diMe POS (n = 279)^{∥∥} | 1.00 (0.99-1.01) | 0.939 |

H3K4diMe MIOD (n = 279)^{¶¶} | 1.01 (0.99-1.02) | 0.443 |

H3K4diMe MOD (n = 279)^{***} | 1.02 (1.00-1.03) | 0.051 |

H3K4diMe MOD (n = 279)^{†††} | 1.56 (1.24-2.66) | 0.019 |

NOTE: All statistical analyses (footnotes ∥ to †††) were done with the highest core value present for each cancer case.

↵*Clinical stage cT

_{1}and cT_{2}(also includes 7 cases cT_{3}).↵

^{†}Pathologic stage pT_{2}and pT_{3}.↵

^{‡}Gleason score <7 vs. ≥ 7.↵

^{§}Preoperative serum PSA level (ng/mL) dichotomized by cutpoint <10.0 vs. ≥10.0.↵

^{∥}Ki67 (% positive cells) as a continuous variable.↵

^{¶}Ki67 (% positive cells) dichotomized by low (<6% positive cells) vs. high (≥6% positive cells).↵**H3K18Ac level (% positive nuclear area) as a continuous variable as measured by VIA.

↵

^{††}H3K18Ac level (% positive nuclear area) dichotomized by low (<50% nuclear area) vs. high (≥50% nuclear area) as measured by VIA.↵

^{‡‡}H3K18Ac MIOD total amount of staining as a continuous variable as measured by VIA.↵

^{§§}H3K18Ac MOD intensity of staining as a continuous variable as measured by VIA.↵

^{∥∥}H3K4diMe level (% positive nuclear area) as a continuous variable as measured by VIA.↵

^{¶¶}H3K4diMe MIOD total amount of staining as a continuous variable as measured by VIA.↵***H3K4diMe MOD intensity of staining as a continuous variable as measured by VIA.

↵

^{†††}H3K4diMe MOD intensity of staining dichotomized by low (<30 MOD) vs. high (≥30 MOD) as measured by VIA.