Table 2.

Results from epidemiologic studies of proposed biological pathways and sedentary behavior

Proposed biological pathwayType of study design, association between sedentary behavior and pathway, and number of studies*
Cross-sectional studiesProspective studies
+Nonsignificant+Nonsignificant
Adiposity42 (12; 16; 39-79)9 (61; 80-88)6 (15; 89-93)5 (94-98)
Sex hormones1 (109)
Metabolic dysfunction4 (52; 101; 105; 108)3 (17; 84; 109)1 (14)3 (89; 106; 107)
Inflammation1 (107)
Vitamin D1 (110)

NOTE: +, Statistically significant, positive (deleterious) association between sedentary behavior and biological pathway; nonsignificant, no statistically significant association between sedentary behavior and biological pathway. None of the studies reviewed reported statistically significant negative associations between sedentary behavior and biological pathway.

  • *Some studies assessed multiple biomarkers and therefore may have multiple associations indicated; some studies produced more than one publication.