Table 4.

Meta-analysis results (advanced or localized cases vs controls)

GeneVariantSNPCases*nDominant effect (a/a | a/A) vs AARecessive effect aa vs (a/A | A/A)Homozygous a/a vs A/AAdditive effect a/a, a/A vs A/A (Reference)
Pooled odds ratio (95% CI)Pooled odds ratio (95% CI)Pooled odds ratio (95% CI)Pooled odds ratio (95% CI)
MTHFR677C>Trs1801133Advanced2,9591.05 (0.94-1.18)1.12 (0.94-1.33)1.14 (0.98-1.33)1.05 (0.98-1.13)
(7 studies; 6,002 controls)Localized3,7631.06 (0.95-1.18)0.99 (0.69-1.41)1.03 (0.73-1.44)§1.03 (0.93-1.15)
Test for heterogeneityP = 0.8P = 0.4P = 0.4P = 0.8
MTHFR1298A>Crs1801131Advanced1,0530.97 (0.84-1.12)0.97 (0.77-1.23)0.96 (0.76-1.23)0.98 (0.88-1.09)
(4 studies; 3,196 controls)Localized1,6940.94 (0.84-1.06)0.93 (0.77-1.14)0.92 (0.74-1.13)0.95 (0.87-1.04)
Test for heterogeneityP = 0.8P = 0.8P = 0.8P = 0.7
MTR2756A>Grs1805087Advanced1,7801.02 (0.91-1.15)0.90 (0.67-1.20)0.91 (0.68-1.22)1.00 (0.91-1.11)
(5 studies; 4,414 controls)Localized2,1871.16 (1.04-1.29)0.97 (0.73-1.28)1.02 (0.76-1.37)1.10 (1.01-1.21)
Test for heterogeneityP = 0.1P = 0.7P = 0.6P = 0.2
MTRR66A>Grs1801394Advanced1,0280.98 (0.84-1.14)1.11 (0.93-1.32)1.07 (0.87-1.31)1.01 (0.91-1.11)
(3 studies; 3,115 controls)Localized1,6331.02 (0.90-1.16)1.01 (0.87-1.17)1.02 (0.86-1.22)1.01 (0.94-1.08)
Test for heterogeneityP = 0.7P = 0.4P = 0.8P = 1.0
MTHFD11958G>Ars2236225Advanced1,6480.97 (0.86-1.10)0.99 (0.80-1.21)0.97 (0.80-1.17)0.98 (0.91-1.07)
(3 studies; 4,053 controls)Localized2,0221.03 (0.84-1.28)1.04 (0.91-1.18)1.03 (0.89-1.21)1.02 (0.93-1.12)
Test for heterogeneityP = 0.7P = 0.6P = 0.6P = 0.6
SLC19A180G>Ars1051266Advanced1,1850.96 (0.83-1.11)0.99 (0.81-1.21)0.96 (0.75-1.24)0.98 (0.87-1.10)
(2 studies; 2,937 controls)Localized1,3741.01 (0.88-1.17)1.05 (0.89-1.23)1.05 (0.87-1.26)1.02 (0.93-1.12)
Test for heterogeneityP = 0.6P = 0.7P = 0.6P = 0.5
SHMT11420C>Trs1979277Advanced9601.11 (0.96-1.28)0.99 (0.78-1.25)1.05 (0.82-1.34)1.06 (0.95-1.18)
(2 studies; 4,110 controls)Localized1,5401.10 (0.98-1.24)1.20 (1.00-1.45)1.24 (1.02-1.51)1.10 (1.01-1.20)
Test for heterogeneityP = 0.9P = 0.2P = 0.3P = 0.6
FOLH11561T>Crs202676Advanced1,1800.95 (0.83-1.10)1.08 (0.80-1.47)1.06 (0.75-1.50)0.98 (0.85-1.13)
(2 studies; 2,922 controls)Localized1,3611.01 (0.84-1.22)0.90 (0.66-1.22)0.91 (0.67-1.25)1.00 (0.90-1.12)
Test for heterogeneityP = 0.5P = 0.4P = 0.5P = 0.7
  • *See Supplementary Table S2 for definitions of “advanced” case within each study.

  • DerSimonian and Laird random effects model (DerSimonian et al., 1986).

  • Q statistic P < 0.001; I2 = 78%.

  • §Q statistic P = 0.001; I2 = 74%.

  • Q statistic P = 0.04; I2 = 54%.

  • Q statistic P = 0.05; I2 = 67%.