Table 3.

Meta-analysis results (all cases vs controls)

GeneVariantSNPStudiesCasesControlsDominant effect (a/a | a/A) vs AARecessive effect aa vs (a/A | A/A)Homozygous a/a vs A/AAdditive effect a/a, a/A vs A/A (ref)
Pooled odds ratio (95% CI)*Pooled odds ratio (95% CI)*Pooled odds ratio (95% CI) *Pooled odds ratio (95% CI) *
MTHFR677C>Trs18011331210,74540,1581.04 (0.97-1.12)1.03 (0.86-1.22)1.05 (0.89-1.23)1.03 (0.98-1.09)
MTHFR1298A>Crs180113153,1764,8290.96 (0.87-1.05)0.90 (0.77-1.05)0.89 (0.76-1.05)0.95 (0.89-1.02)
MTR2756A>Grs180508787,81037,5431.06 (1.00-1.12)1.02 (0.88-1.19)1.04 (0.90-1.21)1.05 (0.99-1.10)
MTRR66A>Grs180139443,0324,5150.95 (0.86-1.05)0.93 (0.76-1.13)0.93 (0.80-1.08)0.96 (0.90-1.03)
MTHFD11958G>Ars223622567,49336,9411.01 (0.95-1.08)1.00 (0.93-1.07)1.01 (0.92-1.09)1.00 (0.96-1.05)
SLC19A180G>Ars105126646,22235,8210.98 (0.92-1.05)1.02 (0.94-1.10)1.00 (0.91-1.09)1.00 (0.95-1.04)
SHMT11420C>Trs197927722,6894,1101.11 (1.00-1.22)1.10 (0.93-1.28)1.15 (0.97-1.35)1.08 (1.00-1.16)
FOLH11561T>Crs20267656,31435,1901.00 (0.93-1.08)0.99 (0.86-1.13)0.99 (0.85-1.15)1.00 (0.93-1.07)
  • *DerSimonian and Laird random effects model (DerSimonian et al., 1986).

  • Q statistic P = 0.001; I2 = 66%.

  • Q statistic P = 0.01; I2 = 56%.