Table 1.

Studies identified by systematic review of the literature

First authorYearCountryCasesControlsPopulationSNPsIncludedReference
Kimura2000Germany132 patients with histopathologically confirmed prostatic carcinoma from the Department of Urology of Heinrich Heine University (Düsseldorf, Germany). Mean age, 65.6 ± 6.0 y (range, 52-89 y).150 patients without malignant disease treated for various abdominal diseases at the Department of Surgery of the Städtische Kliniken (Dortmund, Germany). Sixty-six patients were male and 84 were female. Their mean age was 62.0 ± 11.4 (SD) y (range, 16-90 y).Caucasian (100%)rs1801133Yes(21)
rs1805087
Heijmans2003the Netherlands21 incident prostate cancer cases among 793 men initially without any cancer who were recruited to a population-based longitudinal study to investigate risk factors for chronic diseases in elderly men. Mean age, 71 ± 5 y (range 65-84 y).772 men from the same cohort who did not develop prostate cancer during the 10-y follow-up (but who may have developed other diseases, including other cancers).Caucasian (100%)rs1801133Yes(22)
Cicek2004United States439 cases (diagnosed at age ≤73 y) from 413 families recruited from the major medical institutions in the greater Cleveland, OH area and from the Henry Ford Health System (Detroit, MI). Mean age, 61.0 ± 6.7 y.479 sibling controls <8 y younger than their brother's age at diagnosis. The disease status of unaffected brothers was further confirmed through testing of prostate-specific antigen levels. Mean age, 62.7 ± 9.1 y.Caucasian (91%)rs1801133No (sibling controls)(29)
African-American (8%)rs1801131
Latino (1%)
Singal2004United States81 prostate cancer patients who had radical prostatectomy at the Overton Brooks VA Medical Centre (Shreveport, CA). Mean age, 64 y (range, 49-80 y).42 patients with benign prostatic hyperplasia who had trans-urethral resection of the prostate. Mean age, 70 y (range, 53-88 y).Caucasian (67%)rs1801133Yes(23)
African-American (33%)rs1801131
van Guelpen2006Sweden299 histopathologically confirmed incident prostate cancer cases among 37,776 men recruited to the Northern Swedish Health and Disease Cohort study. Mean age at recruitment was 58.7 ± 4.6 y.617 healthy and cancer-free controls randomly selected from the same cohort and matched 2:1 on age and date of blood sampling. Mean age at recruitment was 58.6 ± 4.6 y.Caucasian (100%)rs1801133Yes(24)
rs1801131
Johansson2007Sweden2,777 histopathologically confirmed cases, diagnosed through a rapid ascertainment scheme at four regional oncological centers, were recruited to a population-based case-control study. Mean age, 65.9 ± 7.2 y.1,639 controls, randomly selected from the Swedish population register and frequency matched to the predicted distribution of cases by age (5-year intervals) and geographic region. Mean age, 67.2 ± 7.4 y.Caucasian (100%)rs1801133Yes(25)
Reljic2007Croatia95 patients diagnosed with histopathologically confirmed prostate cancer at Sestre milosrdnice University hospital, Croatia. Mean age, 69 ± 7 y.37 cancer-free controls recruited as part of a community health screening program in the same geographic region. Controls were given a digital rectal examination and underwent a prostate-specific antigen test. Mean age, 69 ± 7 y.Caucasian (100%)rs1801133Yes(26)
Marchal2008Spain182 patients diagnosed with histopathologically confirmed prostate cancer at the Urology Department of the Hospital Clínico Universitario in Málaga, Spain. Mean age, 70.7 ± 7.3 y.205 patients diagnosed with benign prostatic hyperplasia. These patients were given a digital rectal examination and underwent a prostate-specific antigen test. Mean age, 70.3 ± 7.8 y.Caucasian (100%)rs1801133Yes(27)
rs1801131
rs1805087
rs1801394
Stevens2008United States1,144 incident cases among a subset of men participating in the Cancer Prevention II Nutrition Cohort study who had provided blood samples.1,144 controls from the same cohort matched on age, race, and date of blood sample collection.Caucasian (97%)rs1801133Yes(28)
rs1801131
rs1805087
rs1801394
rs1979277
rs2236225