Table 3.

Association of XRCC2 with colorectal cancer in meta-analysis of U.K. and U.S. studies

SNPGenotypenPhomogeneity*Meta-OR (95% CI)P
ControlsCases
rs3218373GG1,1199831 (Reference)
GT2321930.9 (0.8-1.2)
TT15160.191.2 (0.5-2.9)0.79
rs3218374CC4113701 (Reference)
CG6775590.9 (0.8-1.1)
GG2992690.861.0 (0.8-1.3)0.94
rs3218385TT1,2261,0521 (Reference)
TG or GG1441380.451.1 (0.8-1.4)0.57
rs3218395CC1,2551,0811 (Reference)
CT or TT1371290.351.1 (0.8-1.4)0.51
rs3218400CC1,0689741 (Reference)
CA2752100.8 (0.7-1.0)
AA11160.511.6 (0.7-3.7)0.36
rs3218402AA1,3021,1301 (Reference)
AG or GG70750.891.2 (0.8-1.7)0.35
rs3218418GG1,2451,1031 (Reference)
GA or AA1391070.110.8 (0.6-1.1)0.23
rs3218454AA1,1409991 (Reference)
AT2061670.9 (0.7-1.2)
TT20230.071.3 (0.5-3.4)0.89
rs3218472CC1,3551,1901 (Reference)
CT or TT620.220.4 (0.0-2.7)0.22
rs3218499GG8237121 (Reference)
GC5044141.0 (0.8-1.1)
CC65840.891.6 (1.1-2.2)0.23
CC vs GC or GG0.901.6 (1.1-2.2)0.009
rs3218501CC1,2961,1171 (Reference)
CG or GG100840.241.0 (0.7-1.4)0.93
rs3218536 (R188H)GG1,1671,0141 (Reference)
GA2041851.0 (0.8-1.3)
AA9100.601.3 (0.4-3.8)0.87

NOTE: Case-control comparison, reference genotype is homozygous for major allele; for MAF ≤ 0.05, genotypes were combined because of few subjects (results could not be determined for both novel variants due to very low allele frequencies).

  • *Empirical Q test to assess homogeneity, Phomogeneity based on 10,000 simulations.

  • Empirical Cochran-Mantel-Haenszel Ptrend (additive model) or Pχ2 (dominant or recessive models) based on 10,000 simulations.