Table 1.

Distributionof cases of selected cancers and corresponding controls according to consumption of low-calorie sweeteners, with corresponding ORs and 95% CIs

Cancer siteAll low-calorie sweetenersSaccharinOther sweeteners
NonusersUsersNonusersUsersNonusersUsers
Gastric cancer
    Cases/controls207:47123:71224:5216:23213:49117:51
    OR* (95% CI)10.78 (0.47-1.30)10.62 (0.25-1.55)10.83 (0.46-1.49)
    OR* (95% CI)10.80 (0.45-1.43)10.65 (0.25-1.68)10.86 (0.45-1.67)
Pancreatic cancer
    Cases/controls281:57145:80316:61810:34291:60235:49
    OR* (95% CI)11.15 (0.77-1.70)10.57 (0.28-1.18)11.49 (0.94-2.35)
    OR* (95% CI)10.62 (0.37-1.04)10.19 (0.08-0.46)11.16 (0.66-2.04)
Endometrial cancer
    Cases/controls378:78073:123436:86716:39394:81658:87
    OR* (95% CI)11.21 (0.88-1.66)10.80 (0.44-1.45)11.37 (0.96-1.95)
    OR* (95% CI)10.96 (0.67-1.40)10.71 (0.36-1.38)11.07 (0.71-1.61)

NOTE: The sum does not add up to the total because of missing values.

  • *Estimated by unconditional multiple logistic regression models adjusted for age, sex (when appropriate), and study center (when appropriate).

  • Reference category.

  • Further adjusted for year of interview, education, BMI, tobacco smoking, history of diabetes, consumption of hot beverages, and total energy intake.