Table 2.

Association of BER sequence polymorphisms and colon tumors in current or former smokers

ControlCaseAll casesCaseMSI+CaseCIMP highCaseBRAF mutationCaseKRAS2 mutationCaseTP53 mutation
nn*OR (95% CI)nOR (95% CI)nOR (95% CI)nOR (95% CI)nOR (95% CI)nOR (95% CI)
OGG1S326CCC6205561.0 (Reference)781.0 (Reference)1141.0 (Reference)401.0 (Reference)1161.0 (Reference)1881.0 (Reference)
CG3723211.0 (0.8, 1.2)350.8 (0.6-1.2)500.8 (0.6-1.1)190.8 (0.5-1.4)691.1 (0.8-1.4)1161.1 (0.9-1.4)
GG45541.4 (0.9, 2.2)71.2 (0.5-2.5)80.9 (0.5-1.8)62.1 (0.9-4.7)101.1 (0.6-2.2)141.0 (0.5-1.7)
Ptrend0.440.630.360.430.680.78
GG vs CC/CG1.5 (1.0, 2.2)1.2 (0.6-2.6)1.0 (0.5-1.9)2.2 (1.02-4.9)1.1 (0.6-2.2)0.9 (0.5-1.7)
XRCC1R194WCC9258041.0 (Reference)1041.0 (Reference)1581.0 (Reference)561.0 (Reference)1681.0 (Reference)2691.0 (Reference)
CT/TT1111271.3 (1.0-1.7)161.1 (0.6-1.7)140.6 (0.4-1.0)91.1 (0.6-2.2)271.2 (0.8-1.7)491.4 (1.02-1.9)
XRCC1R280HGG9468471.0 (Reference)1111.0 (Reference)1581.0 (Reference)591.0 (Reference)1771.0 (Reference)2931.0 (Reference)
GA/AA90841.1 (0.8-1.5)90.9 (0.5-1.8)141.0 (0.6-1.7)61.2 (0.5-2.5)181.2 (0.7-1.9)250.9 (0.6-1.4)
XRCC1R399QGG4243931.0 (Reference)471.0 (Reference)741.0 (Reference)331.0871.0 (Reference)1331.0 (Reference)
GA4774241.0 (0.8-1.2)611.2 (0.8-1.7)720.9 (0.7-1.2)210.6 (0.3-0.9)891.0 (0.7-1.3)1451.0 (0.8-1.3)
AA1351140.9 (0.7-1.3)120.8 (0.4-1.5)261.1 (0.8-1.7)111.0 (0.5-2.0)190.7 (0.5-1.2)401.1 (0.7-1.5)
Ptrend0.590.680.900.430.250.93

NOTE: Adjusted for age, sex, race, center, energy, body mass index, activity, long-term alcohol use, recent NSAIDs, and family history.

  • *Includes 689 cases with tumor marker data.

  • Recessive model.