Table 1.

Association of BER sequence polymorphisms and colon tumors

PolymorphismGenotypeControlCaseAll casesCaseMSI+CaseCIMP highCaseBRAF V600ECaseKRAS2 mutationCaseTP53 mutation
nn*OR (95% CI)nOR (95% CI)nOR (95% CI)nOR (95% CI)nOR (95% CI)nOR (95% CI)
OGG1S326CCC1,1729181.0 (Reference)1201.0 (Reference)1841.0 (Reference)601.0 (Reference)2011.0 (Reference)3101.0 (Reference)
CG6865701.1 (0.9-1.2)600.9 (0.7-1.2)800.8 (0.6-1.0)280.8 (0.5-1.3)1351.2 (0.9-1.5)1901.1 (0.9-1.3)
GG93941.3 (1.0-1.8)101.0 (0.5-1.9)130.9 (0.5-1.5)81.7 (0.9-3.5)201.2 (0.8-1.9)271.0 (0.7-1.6)
Ptrend0.090.680.160.740.170.59
GG vs CC/CG1.3 (1.0-1.8)101.1 (0.6-2.0)131.0 (0.6-1.6)81.8 (0.9-3.7)201.1 (0.7-1.8)271.0 (0.7-1.5)
XRCC1R194WCC1,7241,3691.0 (Reference)1661.0 (Reference)2451.0 (Reference)821.0 (Reference)3001.0 (Reference)4501.0 (Reference)
CT/TT2262131.2 (1.0-1.4)241.0 (0.7-1.5)320.9 (0.6-1.3)141.2 (0.7-2.1)561.3 (1.0-1.8)771.2 (1.0-1.6)
XRCC1R280HGG1,7661,4411.0 (Reference)1721.0 (Reference)2541.0 (Reference)851.0 (Reference)3211.0 (Reference)4871.0 (Reference)
GA/AA1841410.9 (0.7-1.2)181.0 (0.7-1.7)230.9 (0.6-1.4)111.3 (0.7-2.4)351.1 (0.8-1.6)400.8 (0.6-1.1)
XRCC1R399QGG8266791.0 (Reference)791.0 (Reference)1221.0 (Reference)501.0 (Reference)1551.0 (Reference)2251.0 (Reference)
GA8727251.0 (0.9-1.2)931.1 (0.8-1.5)1221.0 (0.8-1.2)330.6 (0.4-0.9)1691.1 (0.9-1.3)2421.0 (0.9-1.3)
AA2521780.9 (0.7-1.1)180.8 (0.5-1.3)330.9 (0.6-1.3)130.8 (0.5-1.5)320.8 (0.5-1.1)601.0 (0.7-1.3)
Ptrend0.430.440.410.130.260.73

NOTE: Adjusted for age, sex, race, center, energy, body mass index, activity, long-term alcohol use, smoking, recent NSAIDs, and family history.

  • *Includes 1,210 cases with tumor marker data.

  • Recessive model.