Table 2.

OPRM1 SNPs and association with Rasch-modeled nicotine withdrawal sensitivity

NamePosition*GenomicMAFChisqGlobal PFDR Q
rs1799971154452910Ex1-1730.133.280.07020.0821
rs477292154455500IVS1+24180.2265.730.01670.0586
rs4870266154461111IVS1+80290.0660.0180.89370.5534
rs610231154470590IVS1+175080.1132.190.13900.1463
rs3823010154471265IVS1+181830.1784.140.04180.0599
rs589046154485251IVS1-178230.2615.900.01520.0586
rs563649154500080IVS1-29940.0850.390.53160.5082
rs9322446154500815IVS1-22590.1364.790.02860.0599
rs510587154505541IVS3+7110.0544.000.04550.0599
rs9282821154506488IVS3-300.4130.130.71730.5188
rs3798683154510527IVS4+37590.1944.290.03840.0599
rs599548154510674IVS4+39060.133<0.010.95620.5592
rs623956154522138IVS4-97920.2380.240.62760.5082
rs606148154528099IVS4-38310.0994.290.03830.0599
rs1323041154531293IVS4-6370.4630.070.78860.5188
rs512053154531629IVS4-3010.080.090.76790.5188
rs10485058154537327IVS5+49080.1215.770.01640.0586
rs613355154541962IVS5+95430.3470.240.62340.5082
  • *Chromosome positions are based on NCBI Human Genome Assembly, chr6.

  • Genomic annotation obtained at genewindow.nci.nih.gov.

  • Minor allele frequency of the SNP in the SMOFAM sample.