Table 2.

HRs of recurrences according to baseline serum levels of PDGF and IGF-I

Patients (N)Adjusted HR*Fully adjusted HR
PDGF (quartiles; ng/mL)
1o 2.2-6.62711
2o 6.6-9.3270.6 (0.2-2.1)0.3 (0.1-1.2)
3o 9.5-12.6271.5 (0.5-4.8)1.1 (0.4-4.5)
4o 12.7-26.9263.3 (1.1-9.9)2.3 (0.7-7.1)
IGF-I (quartiles; ng/mL)
1o 58.8-139.22711
2o 139.3-174.4273.3 (1.0-10.6)2.6 (0.8-9.0)
3o 175.4-205.7271.8 (0.5-6.1)2.2 (0.6-8.1)
4o 212.5-420.1262.2 (0.6-8.4)2.0 (0.5-7.7)
Combined PDGF and IGF-I
PDGF and IGF-I ≤ their median value2311
PDGF ≤ the median and IGF-I > the median value311.1 (0.3-4.8)0.7 (0.1-3.0)
PDGF > the median and IGF-I ≤ the median value313.1 (0.9-11.3)1.7 (0.4-7.0)
PDGF and IGF-I > their median value224.0 (1.0-15.2)6.4 (1.5-26.7)
  • * Adjusted for pathologic prognostic factors.

  • Adjusted also for tertiles of body weight and serum testosterone.