Table 3.

Number of cases (n) and SIRs for selected second cancers in SCC of the esophagus patients by follow-up duration

Site of the second cancer (ICD-9)<6 mo
6-11 mo
1-4 y
≥5 y
nSIR (95%CI)nSIR (95%CI)nSIR (95%CI)nSIR (95%CI)
All malignant (140-208)1991.53 (1.33-1.76)590.91 (0.69-1.17)2081.44 (1.25-1.65)1381.03 (0.87-1.22)
    Oral cavity, pharynx (140-149)236.35 (4.02-9.52)95.02 (2.30-9.53)3910.1 (7.17-13.8)144.06 (2.22-6.82)
        Lip (140)32.76 (0.57-8.07)010.94 (0.02-5.24)22.24 (0.27-8.08)
        Tongue (141)510.1 (3.28-23.6)27.79 (0.94-28.1)814.3 (6.16-28.1)36.10 (1.26-17.8)
        Salivary gland (142)13.83 (0.10-21.3)000
        Mouth (143-145)79.89 (3.97-20.4)38.47 (1.75-24.8)911.4 (5.21-21.6)57.38 (2.40-17.2)
        Pharynx (146-149)76.52 (2.62-13.4)47.59 (2.07-19.4)2117.8 (11.0-27.2)43.58 (0.98-9.16)
            Oropharynx (146)12.82 (0.07-15.7)15.90 (0.15-32.9)1129.0 (14.5-51.8)13.30 (0.08-18.4)
            Nasopharynx (147)12.93 (0.07-16.3)012.49 (0.06-13.9)0
            Hypopharynx (148)412.6 (3.42-32.1)318.5 (3.82-54.1)515.1 (4.90-35.2)26.60 (0.80-23.8)
            Pharynx, unspecified (149)117.0 (0.42-94.5)0457.5 (15.7-0147)117.3 (0.43-96.2)
    Stomach (151)282.82 (1.87-4.07)30.62 (0.13-1.81)131.35 (0.72-2.31)70.79 (0.32-1.62)
    Liver (155) (-155.2)63.37 (1.24-7.33)22.25 (0.27-8.12)41.90 (0.52-4.87)10.40 (0.01-2.23)
Larynx (161)21.34 (0.16-4.85)11.36 (0.03-7.56)85.02 (2.17-9.88)64.19 (1.54-9.11)
Lung (162)301.47 (0.99-2.10)60.60 (0.22-1.31)431.98 (1.43-2.67)331.64 (1.13-2.31)
Female breast (174)40.46 (0.12-1.17)61.21 (0.44-2.63)110.87 (0.43-1.56)100.96 (0.46-1.76)
Cervix uteri (180)011.66 (0.04-9.25)21.40 (0.17-5.07)21.96 (0.24-7.10)
Prostate (185)211.24 (0.77-1.89)70.85 (0.34-1.75)170.99 (0.58-1.58)100.57 (0.27-1.04)
Testis (186)0018.48 (0.21-47.2)0
Bladder (188,189.3,189.4)91.39 (0.64-2.65)20.64 (0.08-2.32)91.34 (0.61-2.55)81.30 (0.56-2.56)
Kidney (189) (-189.3,189.4)103.09 (1.48-5.68)31.82 (0.38-5.31)82.22 (0.96-4.36)10.31 (0.01-1.75)
Thyroid gland (193)34.71 (0.97-13.8)033.99 (0.82-11.7)11.50 (0.04-8.37)
Non–Hodgkin lymphoma (200, 202)30.96 (0.20-2.81)020.54 (0.06-1.94)10.29 (0.01-1.60)