Table 2.

DNA repair polymorphisms and breast cancer risk

Genotype*Cases
Controls
Unadjusted
Ethnicity adjusted
n (%)n (%)Odds ratio (95% confidence interval)POdds ratio (95% confidence interval)P
Rad51 (n = 1,222)
    GG516 (84.5)513 (84.0)1.000.671.000.91
    GC88 (14.4)88 (14.4)0.99 (0.72-1.36)1.05 (0.76-1.45)
    CC7 (1.1)10 (1.6)0.67 (0.24-1.87)0.68 (0.24-1.94)
    GG vs GC/CC1.04 (0.76-1.41)0.821.02 (0.74-1.39)0.92
XRCC2 (n = 1,204)
    GG515 (85.5)519 (86.2)1.000.821.000.77
    GA83 (13.8)78 (13.0)1.07 (0.77-1.50)1.08 (0.77-1.52)
    AA4 (0.7)5 (0.8)0.81 (0.22-3.01)0.83 (0.22-3.12)
    GG vs GA/AA1.06 (0.76-1.47)0.741.07 (0.77-1.48)0.71
XRCC3 (n = 1,222)
    CC254 (41.6)249 (40.8)1.000.471.000.77
    CT259 (42.4)286 (46.8)0.88 (0.68-1.13)0.83 (0.64-1.08)
    TT98 (16.0)76 (12.4)1.28 (0.89-1.83)1.20 (0.83-1.72)
  • * Using the χ2 test, no significant difference in genotype frequencies was observed between cases and controls.

  • Matched pairs were excluded if either member of the pair could not be definitively genotyped.

  • P for trend.