Table 1.

Characteristics of cases and controls

VariablesCases (n = 612)Controls (n = 612)Odds ratio (95% confidence interval)*P*
Age at diagnosis (y)
    Median (25th, 75th percentile)60.3 (51.8, 66.6)60.3 (51.8, 66.6)Matched
Body mass index (kg/m2),
    Median (25th, 75th percentile)
    Age ≤52 y22.8 (20.9, 25.4)23.1 (21.4, 25.0)0.56 (0.11-2.75)0.47
    Age >52 y25.2 (22.5, 28.4)24.2 (22.0, 27.6)2.20 (1.00-4.82)0.05
Height (cm)
    Median (25th, 75th percentile)163 (157, 168)163 (157, 168)1.00 (0.99-1.02)0.72
Ethnicity, n (%)
    Caucasian
        Non-Jewish222 (39.7)202 (36.9)1.000.02
        Jewish254 (45.4)232 (42.4)1.02 (0.77-1.35)
    Black50 (8.9)59 (10.8)0.77 (0.49-1.21)
    Others (including Hispanic and Asian)33 (5.9)54 (9.9)0.49 (0.29-0.81)
    Unknown5365
Family history, n (%)
    None468 (76.5)475 (77.6)1.000.31§
    1 affected relative, >45 y76 (12.4)85 (13.9)0.91 (0.66-1.27)
    1 affected relative, age unknown15 (2.5)12 (2.0)1.24 (0.58-2.65)
    >1 affected relative or 1 age <45 y53 (8.7)40 (6.5)1.33 (0.87-2.04)
Age at menarche (y), n (%)
    <13309 (50.5)286 (46.7)1.00
    ≥13303 (49.5)326 (53.3)0.87 (0.70-1.08)0.20
Number of pregnancies, n (%)
    Nulliparous201 (37.2)180 (32.1)1.000.19§
    162 (11.5)81 (14.5)0.73 (0.48-1.10)
    2153 (28.3)173 (30.9)0.77 (0.56-1.06)
    ≥3125 (23.1)126 (22.5)0.82 (0.58-1.15)
    Unknown7152
Age at first term pregnancy (y), n (%)
    <25142 (23.2)183 (29.9)1.000.0002§
    25-29168 (27.5)180 (29.4)1.21 (0.88-1.66)
    Nulliparous201 (32.8)180 (29.4)1.47 (1.08-1.99)
    >30101 (16.5)69 (11.3)1.96 (1.32-2.89)
Smoking status, n (%)
    Never253 (47.7)253 (48.8)1.000.35
    Ever278 (52.4)265 (51.2)0.99 (0.76-1.29)
    Unknown8194
  • * Odds ratios and P values are for conditional univariate regression analysis.

  • Using ln of body mass index (at baseline) as a continuous variable.

  • A division at the age of 52 y was decided upon a priori as a surrogate for menopausal status.

  • § P for trend using ordered categories shown in this table.