Table 3.

Multivariable analysis of the relationship between ovarian cancer risk according to the presence of cyclin E overexpression and composite LOC variable and components of LOC variable

Cyclin E+ case versus control
Cyclin E- case versus control
OR* (95% CI)POR* (95% CI)P
Composite LOC variable (per 60 cycles)1.18 (1.08-1.30)0.0011.05 (0.98-1.14)0.181
Other covariates
    Tubal ligation (yes/no)0.61 (0.42-0.89)0.0110.57 (0.41-0.80)0.001
    Family history of breast/ovarian cancer in first-degree relative (yes/no)1.30 (0.94-1.79)0.1201.14 (0.83- 1.56)0.413
    BMI (kg/m2)1.02 (1.00-1.05)0.1281.02 (1.00-1.05)0.030
    Infertility (yes/no)1.91 (1.29- 2.84)0.0011.26 (0.87-1.83)0.227
LOC component
    Age at menarche (per year)0.99 (0.88-1.11)0.8300.94 (0.86-1.03)0.186
    Age at last period (per year)1.01 (0.97-1.05)0.6111.03 (0.99-1.07)0.132
    Breast-feeding exclusively (per year)0.70 (0.41-1.21)0.1990.96 (0.65-1.40)0.820
    Pregnancy (per year)0.81 (0.67-0.98)0.0260.89 (0.76-1.04)0.148
    Oral contraceptive use (per year)0.91 (0.87-0.95)<0.00010.99 (0.96-1.02)0.318
    Irregular cycles (per year)0.97 (0.94-1.00)0.0740.98 (0.96-1.01)0.203
    Missed periods (per 12 periods)1.02 (1.00-1.04)0.0761.00 (0.98-1.02)0.984
    HRT duration (per year)1.02 (0.99-1.05)0.1871.03 (1.00-1.06)0.022
Other covariates
    Tubal ligation (yes/no)0.64 (0.42-0.98)0.0400.60 (0.42-0.85)0.005
    Family history of breast/ovarian cancer in first-degree relative (yes/no)1.26 (0.90-1.76)0.1791.17 (0.85-1.60)0.341
    BMI (kg/m2)1.02 (1.00- 1.05)0.0671.03 (1.00- 1.05)0.019
    Infertility (yes/no)1.80 (1.19- 2.73)0.0061.26 (0.85- 1.86)0.247
  • NOTE: n = 205 cyclin E+ cases, n = 166 cyclin E-cases, and n = 572 controls.

  • * Adjusted for age at diagnosis/interview (cubic spline), race (Black/non-Black), BMI (kg/m2; continuous), tubal ligation (yes/no), family history of breast/ovarian cancer in first-degree relative (yes/no), and infertility (yes/no).