Table 2.

Comparisons of demographic and epidemiologic characteristics between control subjects and ovarian cancer cases, stratified by cyclin E overexpression

VariablesCyclin E+ cases (n = 218)Cyclin E cases (n = 320)Controls (n = 629)Cyclin E+ cases vs controls
Cyclin E cases vs controls
PP
Age
    Mean (SD)56.0 (11.6)52.9 (11.5)54.8 (12.2)0.1980.026
    Median (range)57 (21-74)53 (20-74)54 (20-75)
Age (y) at menopause
n147178378
    Mean (SD)49.2 (4.7)49.2 (5.0)48.9 (5.1)0.5690.587
    Median (range)50 (33-59)50 (26-64)50 (25-65)
Age (y) at menarche
    Mean (SD)12.6 (1.4)12.5 (1.7)12.6 (1.5)0.9760.212
    Median (range)13 (9-17)12 (8-17)13 (9-19)
n (%)n (%)n (%)
Race
    White192 (88)262 (82)529 (84)0.1810.619
    Black20 (9)49 (15)87 (14)
    Other6 (3)9 (3)13 (2)
Menopause status
    Pre/peri71 (33)140 (44)250 (40)0.0600.236
    Post147 (67)180 (56)379 (60)
Months breast-feeding
    None166 (76)221 (69)405 (64)0.0060.120
    1-529 (13)59 (18)117 (19)
    6-1220 (9)29 (9)81 (13)
    >123 (1)11 (3)26 (4)
Months pregnant
    None37 (17)52 (16)61 (10)0.0030.002
    1-810 (5)21 (7)23 (4)
    9-1878 (36)116 (36)231 (37)
    19-3677 (35)109 (34)252 (40)
    >3615 (7)21 (7)61 (10)
Years of oral contraceptive use
    None87 (40)104 (33)203 (32)<0.00010.862
    ≤594 (43)114 (36)239 (38)
    >534 (16)92 (29)178 (28)
    Unknown3 (1)10 (3)9 (1)
Irregular cycles (y)
    None144 (68)206 (68)399 (65)0.6050.851
    <338 (18)55 (18)114 (19)
    3-510 (5)7 (2)33 (5)
    >521 (10)37 (120)66 (11)
    Missing51517
HRT (y)
    Never110 (50)190 (59)375 (60)0.0050.223
    <15 (2)9 (3)18 (3)
    1-<532 (15)44 (14)84 (13)
    5-<1021 (10)21 (7)47 (7)
    >1042 (19)46 (14)78 (12)
    Missing8 (4)10 (3)27 (4)
Hysterectomy
    No168 (77)228 (72)493 (79)0.7570.048
    Before menopause45 (21)81 (25)124 (20)
    After menopause5 (2)9 (3)10 (2)
    Hysterectomy but DK when012
    Missing010
Family history of breast/ovarian cancer in a first-degree relative
    No172 (79)266 (83)526 (84)0.1040.804
    Yes46 (21)54 (17)102 (16)
BMI 1 y before diagnosis/interview (kg/m2)
    <2590 (42)122 (39)255 (42)0.4290.032
    25-29.959 (28)83 (27)190 (31)
    ≥3065 (30)107 (34)166 (27)
    Missing4818
Tubal ligation
    No167 (77)239 (75)415 (66)0.0040.006
    Yes51 (23)81 (25)214 (34)
Infertility
    No164 (75)261 (82)526 (84)0.0040.366
    Yes54 (25)59 (18)101 (16)