Table 3.

Polymorphisms associated with P values < 0.05 in the SNP500Cancer-Illumina OPA and risk of colorectal cancer, using the dominant genetic model, in the NHS and HPFS

SNP IDSNP500Cancer IDNucleotide positionCases (n)Controls (n)Conditional OR*,
rs3774937IL10-17-3584A>T1591321.0
159 + 43*175 + 54*1.35 (1.01-1.81)
rs2236771PLA2G2A-03T32T; Ex4 + 56G>C2973191.0
61 + 1*40 + 0*0.63 (0.42-0.95)
rs1537234GSTM3-06IVS7-30G>T1361081.0
172 + 53*190 + 62*1.42 (1.04-1.94)
rs2066470MTHFR-03P39P Ex2-120C>T2763021.0
81 + 2*56 + 3*0.66 (0.45-0.95)
rs879332HSD3B2-25-17124G>A87931.0
161 + 113*190 + 78*0.92 (0.66-1.28)
rs4149371TP5313-18-578A>G3213371.0
38 + 1*23 + 0*0.58 (0.34-0.98)
rs2289019HADHA-10IVS13-163C>G2362091.0
113 + 12*133 + 19*1.36 (1.01-1.83)
rs256567PMS1-54IVS9-938C>T2732891.0
80 + 7*70 + 0*0.75 (0.52-1.08)
rs4673222FSD7-20Ex1-1251G>A3232971.0
35 + 3*62 + 1*1.83 (1.18-2.86)
rs1049216CASP3-08Ex8 + 567A>G2131771.0
122 + 24*159 + 24*1.53 (1.13-2.07)
rs1405938CASP3-07IVS3-46A>G2222461.0
119 + 18*102 + 12*0.75 (0.55-1.02)
rs3087455CASP3-02IVS2-1555A>C1661441.0
164 + 30*173 + 43*1.28 (0.95-1.73)
rs3774937NFKB1-02IVS1 + 11306C>T1871531.0
136 + 38*161 + 46*1.48 (1.09-2.00)
rs4648059NFKB1-21IVS12-452C>G3233381.0
35 + 2*23 + 0*0.60 (0.35-1.03)
Poly-0009047HSD17B4-08Ex24-76A>G3083261.0
49 + 2*32 + 0*0.62 (0.39-1.00)
Poly-0009064GHR-21IVS2 + 29065C>T2292501.0
114 + 18*101 + 8*0.75 (0.55-1.02)
rs6179GHR-01G186G; Ex6-61A>G1882111.0
142 + 31*132 + 17*0.79 (0.59-1.05)
rs6413428SEPP1-02Ex5 + 710A>G2112311.0
125 + 25*117 + 13*0.81 (0.61-1.08)
rs2235718FOXC1-02-3077C>T3062781.0
49 + 5*75 + 7*1.64 (1.12-2.38)
rs9405496FOXC1-13-2049A>C2962711.0
59 + 6*81 + 9*1.50 (1.05-2.15)
rs998075IGF2R-02T713T; Ex16 + 88A>G841101.0
189 + 88*176 + 75*0.67 (0.47-0.95)
rs5369EDN1-01E106E; Ex3-72A>G2922621.0
61 + 6*92 + 6*1.65 (1.15-2.38)
rs2282151NFKB1E-03*760bp 3′ of STP G>A2362101.0
108 + 17*122 + 29*1.34 (1.00-1.80)
rs1549760CDK5-16-903G>A2282091.0
120 + 13*124 + 27*1.22 (0.92-1.62)
rs2979895POLB-16IVS2-2264G>A3183021.0
41 + 1*53 + 6*1.53 (0.98-2.39)
E3663_301TERF1-02IVS7 + 82C>T2082281.0
132 + 21*123 + 9*0.77 (0.56-1.05)
rs3891248MYC-02IVS1-355A>T2792541.0
74 + 7*96 + 11*1.44 (1.03-2.01)
rs10082466MBL2-27Ex4-1483T>C1972251.0
141 + 23*122 + 14*0.73 (0.54-0.98)
Poly-0014684GPX2-07*2680bp 3′ of STP T>A3243081.0
34 + 0*51 + 2*1.61 (1.03-2.52)
rs4924496RAD51-17IVS3 + 1932T>C1131351.0
173 + 75*170 + 56*0.76 (0.55-1.04)
rs730154CYP19A1-16IVS2 + 24809A>G2332661.0
108 + 19*81 + 13*0.65 (0.48-0.89)
rs1869145LIPC-25IVS1-33033C>T2042331.0
132 + 20*113 + 12*0.71 (0.52-0.95)
rs1968689LIPC-37IVS1-7747C>T3203001.0
39 + 2*59 + 2*1.59 (1.03-2.44)
rs2159116FANCA-34IVS27-36G>T2572371.0
78 + 12*96 + 18*1.42 (1.02-1.97)
Poly-0014870STK6-08*800bp 3′ of STP G>C2702471.0
86 + 5*105 + 9*1.43 (1.01-2.02)
rs10485805STK6-16IVS9-68T>C2382111.0
109 + 14*128 + 22*1.40 (1.03-1.92)
rs4646312COMT-16IVS1-385C>T1081291.0
178 + 74*181 + 50*0.80 (0.59-1.07)
rs4680COMT-01V158M; Ex4-12G>A106841.0
180 + 66*183 + 86*0.70 (0.48-1.01)
  • NOTE: Heterozygotes + variant homozygous compared with the common homozygous variant.

  • * Conditional logistic regression conditioned on the strata defined by the matching variables.

  • Wild-type reference compared with variant carriers.