Table 4.

Odds ratios of colorectal cancer (95% confidence intervals) by increase in HbA1c in women, by cancer site

Quintiles
OR per 10% increase in HbA1c
12345
Colorectum≤5.4]5.4-5.6]]5.6-5.8]]5.8-6.1]>6.1
    No. cases/controls96/9184/10985/114118/9782/54
    Crude*1.000.72 (0.47-1.09)0.71 (0.46-1.09)1.14 (0.75-1.73)1.46 (0.91-2.33)1.19 (1.04-1.35)
    Adjusted1.000.74 (0.48-1.13)0.71 (0.46-1.10)1.13 (0.74-1.71)1.40 (0.87-2.24)1.16 (1.01-1.32)
    Nondiabetics≤5.4]5.4-5.6]]5.6-5.7]]5.7-5.9]>5.9
    No. cases/controls90/8079/9939/5377/87105/71
    Adjusted1.000.72 (0.46-1.13)0.69 (0.41-1.16)0.78 (0.49-1.23)1.32 (0.83-2.10)1.28 (0.99-1.67)
Colon≤5.4]5.4-5.6]]5.6-5.8]]5.8-6.1]>6.1
    No. cases/controls62/5551/6656/8082/6751/34
    Crude*1.000.67 (0.39-1.13)0.62 (0.37-1.04)1.09 (0.66-1.79)1.34 (0.75-2.38)1.15 (0.97-1.37)
    Adjusted1.000.69 (0.40-1.18)(0.63 0.37-1.05)1.09 (0.66-1.82)1.30 (0.72-2.33)1.12 (0.93-1.34)
    Nondiabetics≤5.4]5.4-5.6]]5.6-5.7]]5.7-5.9]>5.9
    No. cases/controls57/5048/6022/3854/6079/52
    Adjusted1.000.73 (0.42-1.27)0.55 (0.28-1.06)0.79 (0.46-1.37)1.38 (0.80-2.38)1.32 (0.96-1.80)
Rectum≤5.4]5.4-5.6]]5.6-5.8]]5.8-6.1]>6.1
    No. cases/controls34/3633/4329/3436/3031/20
    Crude*1.000.84 (0.41-1.72)0.95 (0.44-2.06)1.29 (0.61-2.74)1.75 (0.78-3.92)1.24 (1.01-1.52)
    Adjusted1.000.86 (0.41-1.78)0.95 (0.44-2.07)1.28 (0.60-2.73)1.67 (0.74-3.78)1.22 (0.99-1.50)
    Nondiabetics≤5.4]5.4-5.6]]5.6-5.7]]5.7-5.9]>5.9
    No. cases/controls33/3031/3917/1523/2726/19
    Adjusted1.000.71 (0.32-1.55)0.99 (0.40-2.46)0.72 (0.30-1.72)1.15 (0.47-2.79)1.21 (0.74-1.97)
  • * Analysis matched on EPIC recruitment center, gender, age at blood donation, time of the day at blood donation, follow-up time, fasting status and, in women, menopausal status and phase of the menstrual cycle for premenopausal women.

  • Adjustment for WHR and alcohol.