Table 3.

Odds ratios of colorectal cancer (95% confidence intervals) by increase in HbA1c in men, by cancer site

Quintiles
OR per 10% increase in HbA1c
12345
Colorectum≤5.4]5.4-5.6]]5.6-5.8]]5.8-6.1]>6.1
    No. cases/controls118/127109/103104/110116/120114/101
    Crude*1.001.14 (0.79-1.65)1.03 (0.71-1.51)1.05 (0.72-1.54)1.25 (0.84-1.86)1.06 (0.96-1.18)
    Adjusted1.001.17 (0.80-1.69)1.04 (0.71-1.53)1.09 (0.74-1.60)1.25 (0.83-1.86)1.06 (0.95-1.17)
    Nondiabetics≤5.4]5.4-5.6]]5.6-5.7]]5.7-5.9]>5.9
    No. cases/controls112/11294/9056/467.9/93101/101
    Adjusted1.001.05 (0.71-1.56)1.27 (0.78-2.05)0.87 (057-1.33)0.99 (0.65-1.51)0.94 (0.75-1.17)
Colon≤5.4]5.4-5.6]]5.6-5.8]]5.8-6.1]>6.1
    No. cases/controls68/7470/6363/7274/7567/58
    Crude*1.001.23 (0.75-2.03)0.98 (0.60-1.61)1.10 (0.67-1.80)1.32 (0.78-2.23)1.10 (0.96-1.26)
    Adjusted1.001.31 (0.79-2.16)1.03 (0.62-1.70)1.12 (0.68-1.85)1.27 (0.75-2.17)1.08 (0.94-1.24)
    Nondiabetics≤5.4]5.4-5.6]]5.6-5.7]]5.7-5.9]>5.9
    No. cases/controls65/6560/5238/3043/5765/67
    Adjusted1.001.19 (0.69-2.05)1.31 (0.71-2.43)0.82 (0.46-1.45)0.92 (0.54-1.58)0.92 (0.68-1.23)
Rectum≤5.4]5.4-5.6]]5.6-5.8]]5.8-6.1]>6.1
    No. cases/controls50/5339/4041/3842/4547/43
    Crude*1.001.03 (0.59-1.78)1.15 (0.64-2.10)1.01 (0.55-1.85)1.19 (0.65-2.19)1.02 (0.87-1.19)
    Adjusted1.000.94 (0.53-1.65)1.18 (0.63-2.20)1.04 (0.55-1.94)1.35 (0.71-2.56)1.03 (0.88-1.21)
    Nondiabetics≤5.4]5.4-5.6]]5.6-5.7]]5.7-5.9]>5.9
    No. cases/controls47/4734/3818/1636/3636/34
    Adjusted1.000.84 (0.46-1.53)1.34 (0.60-3.02)1.01 (0.52-1.99)1.17 (0.58-2.35)0.97 (0.67-1.38)
  • * Analysis matched on EPIC recruitment center, gender, age at blood donation, time of the day at blood donation, follow-up time, fasting status and, in women, menopausal status and phase of the menstrual cycle for premenopausal women.

  • Adjustment for WHR and alcohol (g/d).