Table 2.

Odds ratios of colorectal cancer (95% CI) by increase in HbA1c in cases and in matched controls in the study population, by cancer site

Quintiles
OR per 10% increase in HbA1c
12345
Colorectum≤5.4]5.4-5.6]]5.6-5.8]]5.8-6.1]>6.1
    No. cases/controls214/218193/212189/224234/217196/155
    Crude*1.000.93 (0.71-1.23)0.87 (0.66-1.16)1.11 (0.84-1.47)1.33 (0.98-1.80)1.11 (1.03-1.20)
    Adjusted1.000.96 (0.73-1.27)0.88 (0.66-1.17)1.13 (0.85-1.49)1.30 (0.96-1.77)1.10 (1.01-1.19)
    Nondiabetics≤5.4]5.4-5.6]]5.6-5.7]]5.7-5.9]>5.9
    No. cases/controls202/192173/18995/99156/180206/172
    Adjusted1.000.89 (0.66-1.19)0.94 (0.66-1.33)0.84 (0.61-1.14)1.15 (0.85-1.57)1.07 (0.90-1.27)
Colon≤5.4]5.4-5.6]]5.6-5.8]]5.8-6.1]>6.1
    No. cases/controls130/129121/129119/152156/142118/92
    Crude*1.000.93 (0.65-1.33)0.78 (0.55-1.11)1.10 (0.77-1.55)1.30 (0.88-1.91)1.12 (1.01-1.24)
    Adjusted1.000.97 (0.67-1.39)0.80 (0.56-1.14)1.10 (0.77-1.56)1.25 (0.84-1.84)1.09 (0.98-1.22)
    Nondiabetics≤5.4]5.4-5.6]]5.6-5.7]]5.7-5.9]>5.9
    No. cases/controls122/115108/11260/6897/117144/119
    Adjusted1.000.93 (0.64-1.37)0.86 (0.55-1.34)0.80 (0.54-1.17)1.15 (0.79-1.68)1.09 (0.88-1.34)
Rectum≤5.4]5.4-5.6]]5.6-5.8]]5.8-6.1]>6.1
    No. cases/controls84/8972/8370/7278/7578/63
    Crude*1.000.93 (0.61-1.44)1.08 (0.68-1.73)1.15 (0.72-1.83)1.40 (0.86-2.27)1.10 (0.98-1.24)
    Adjusted1.000.91 (0.59-1.42)1.07 (0.66-1.73)1.15 (0.72-1.85)1.45 (0.88-2.38)1.10 (0.97-1.25)
    Nondiabetics≤5.4]5.4-5.6]]5.6-5.7]]5.7-5.9]>5.9
    No. cases/controls80/7765/7735/3159/6362/53
    Adjusted1.000.81 (0.51-1.29)1.12 (0.62-2.02)0.91 (0.54-1.53)1.17 (0.68-2.01)1.04 (0.78-1.38)
  • * Analysis matched on EPIC recruitment center, gender, age at blood donation, time of the day at blood donation, follow-up time, fasting status and, in women, menopausal status and phase of the menstrual cycle for premenopausal women.

  • Adjustment for WHR and alcohol (g/d).