Table 2.

Mean PAH-DNA adduct levels in prostate tumor and adjacent nontumor prostate cells for smoking and genotypes in PAH metabolism and conjugation genes

Variable/genotypeTumor cells
Nontumor cells
Mean ± SE*PMean ± SE*P
Ever smoker
    No0.1585 ± 0.00490.2244 ± 0.0072
    Yes0.1680 ± 0.00380.130.2284 ± 0.00550.66
Current smoker
    No0.1632 ± 0.00330.2256 ± 0.0048
    Yes0.1749 ± 0.00940.250.2407 ± 0.01310.30
CYP1B1 Ala119Ser
    Ala/Ala0.1671 ± 0.00480.2294 ± 0.0069
    Ala/Ser0.1638 ± 0.00490.620.2252 ± 0.00700.67
    Ser/Ser0.1671 ± 0.00830.990.2383 ± 0.01210.53
CYP1B1 Leu432Val
    Leu/Leu0.1663 ± 0.00640.2136 ± 0.0094
    Leu/Val0.1686 ± 0.00460.510.2300 ± 0.00680.16
    Val/Val0.1602 ± 0.00490.690.2340 ± 0.00720.09
CYP1A1 Ile462Val
    Ile/Ile0.1651 ± 0.00320.2284 ± 0.0047
    Ile/Val0.1746 ± 0.01490.540.2287 ± 0.02190.98
    Val/Val
CYP3A4 A(−392)G
    A/A0.1624 ± 0.00400.2227 ± 0.0059
    A/G0.1737 ± 0.00620.120.2347 ± 0.00910.27
    G/G0.1598 ± 0.00720.760.2305 ± 0.01050.52
mEH Tyr113His
    Tyr/Tyr0.1699 ± 0.00430.2383 ± 0.0063
    Tyr/His0.1695 ± 0.00510.960.2246 ± 0.00750.16
    His/His0.1786 ± 0.01290.520.2500 ± 0.01890.56
mEH His139Arg
    His/His0.1687 ± 0.00450.2272 ± 0.0064
    His/Arg0.1660 ± 0.00490.680.2227 ± 0.00710.57
    Arg/Arg0.1521 ± 0.00960.120.2220 ± 0.01380.73
GSTM1 null deletion
    +/− or +/+0.1631 ± 0.00390.2283 ± 0.0057
    −/−0.1694 ± 0.00480.310.2275 ± 0.00710.94
GSTP1 Ile105Val
    Ile/Ile0.1613 ± 0.00500.2283 ± 0.0073
    Ile/Val0.1650 ± 0.00430.570.2264 ± 0.00630.84
    Val/Val0.1709 ± 0.00780.300.2250 ± 0.01140.81
  • NOTE: All analyses were adjusted for age, smoking, alcohol, ethnicity, Gleason score, tumor stage, and PSA at diagnosis.

  • * Mean absorbance units and SE of mean.

  • P value for tests comparing wild-type/variant to wild-type/wild-type and variant/variant to wild-type/wild-type. P value shown is not corrected for multiple tests.

  • Not estimated because no subjects had this genotype.