Table 1.

Characteristics of the case-control samples

Case, n (%)Control, n (%)TotalSNP2 (n = 947) MAF (allele A)SNP6 (n = 932) MAF (allele T)SNP7 (n = 937) MAF (allele G)
Gender
    Female208 (42.7)244 (46.0)4520.440.390.04
    Male279 (57.3)287 (54.0)5660.480.370.05
Age group (y)
    20-4990 (18.5)101 (19.0)1910.440.350.05
    50-59117 (24.0)117 (22.0)2340.450.380.04
    60-69123 (25.3)142 (26.7)2650.480.390.04
    70+157 (32.2)171 (32.2)3280.470.390.04
Ethnicity
    Caucasian387 (79.5)420 (79.1)8070.440.370.03
    Asian48 (9.9)59 (11.1)1070.660.480.13
    South Asian14 (2.9)24 (4.5)380.510.350.06
    Mixed/other23 (4.7)17 (3.2)400.380.290.05
    Unknown/refused15 (3.1)11 (2.1)260.420.370.09
Region
    Vancouver402 (82.5)408 (76.8)8100.460.370.05
    Victoria85 (17.5)123 (23.2)2080.480.410.03
NHL subtypes
    B-cell lymphomas442 (90.8)0.430.370.04
        DLBC124 (25.5)0.470.410.04
        FSC*92 (18.9)0.380.330.04
        FM/FL*48 (9.9)0.420.370.04
        MZ/MALT48 (9.9)0.410.390.03
        MCLD31 (6.4)0.290.210.09
        SLL21 (4.3)0.530.500.00
        LPL23 (4.7)0.550.380.00
        Miscellaneous BCL55 (11.3)0.400.380.03
    T-cell lymphomas44 (9.0)0.410.320.05
        MF23 (4.7)0.550.430.05
        PTCL15 (3.1)0.290.190.04
        Miscellaneous TCL6 (1.2)0.170.170.08
    Miscellaneous/NOS1 (0.2)0.000.000.00
Total4875311,018
  • NOTE: P values for differences in socio-demographic characteristics between cases and controls were as follows: gender, 0.30; age group, 0.88; ethnicity, 0.32; and region, 0.024. All analyses have been adjusted for these four characteristics, however, so the slight regional difference between cases and controls will not affect our results.

    Abbreviations: DLBC, diffuse large T-cell lymphoma; FSC, follicular small cell lymphoma; FM, follicular mixed cell; MZL/MALT, marginal zone lymphoma/mucosa-associated lymphoid tissue lymphomas; MCLD, mantle cell lymphoma diffuse; SLL, small lymphocytic lymphoma; LPL, lymphoplasmacytic lymphoma; MF, mycosis fungoides; PTCL, peripheral T-cell lymphoma; BCL, B-cell lymphoma; TCL, T-cell lymphoma; NOS, not otherwise specified; MAF, minor allele frequency.

  • * Follicular small cell lymphoma and follicular mixed cell/FL were combined for analysis as follicular lymphoma.